Elsevier

Journal of Hepatology

Volume 61, Issue 5, November 2014, Pages 1158-1165
Journal of Hepatology

Review
Health related quality of life in people with advanced chronic liver disease

https://doi.org/10.1016/j.jhep.2014.06.034Get rights and content
Under a Creative Commons license
open access

Summary

Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease.

Abbreviations

ARLD
alcohol related liver disease
NAFLD
non-alcoholic fatty liver disease
HCC
hepatocellular carcinoma
HRQOL
health related quality of life
QALY
quality adjusted life year
SF-36
short form-36
PCS
physical component summary
MCS
mental component summary
PF
physical function
RF
role physical
BP
bodily pain
GH
general health
VT
vitality
SF
social function
RE
role emotional
MH
mental health
SIP
sickness impact profile
NHP
Nottingham health profile
CLDQ
chronic liver disease questionnaire
LDQOL
liver disease quality of life
SF-LDQOL
short form-liver disease quality of life
LDSI
liver disease symptom index
CPS
Child-Pugh score
MELD
model for end stage liver disease
PBC
primary biliary cirrhosis
HCV
hepatitis C virus
HBV
hepatitis B virus
PROMIS-CAT
patient reported outcomes measurement information system computerised adaptive test
MFI-20
multidimensional fatigue index-20
HE
hepatic encephalopathy
TIPS
transjugular intrahepatic portosystemic shunt
RCT
randomised controlled trial
OHE
overt hepatic encephalopathy
MHE
minimal hepatic encephalopathy
BMI
body mass index

Keywords

Cirrhosis
Liver
Health related quality of life
Quality of life

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