ReviewAutophagy and senescence in fibrosing cholangiopathies
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Abbreviations
BA
biliary atresia
EMT
epithelial-mesenchymal transition
PAMP
pathogen-associated molecular patterns
PBC
primary biliary cirrhosis
PSC
primary sclerosing cholangitis
SASP
senescence-associated secretory phenotype
TLR
Toll-like receptor
TRAIL
tumor factor-related apoptosis-inducing ligand
CNSDC
chronic nonsuppurative destructive cholangitis
AMA
antimitochondrial antibodies
SA-β-gal
senescence-associated β-galactosidase
LPS
lipopolysaccharide
MyD88
myeloid differentiation factor 88
IRAK-1, IL-1
receptor-associated kinase-1
dsRNA
double-stranded RNA
IRF-3
interferon regulatory factor 3
PDC-E2
pyruvate dehydrogenase complex-E2
LC3
light chain 3β
MHC
major histocompatibility complex
pANCA
perinuclear anti-neutrophil cytoplasmic antibody
BEC-Abs
biliary epithelial cell antibodies
Keywords
Fibrosing cholangiopathy
Cellular senescence
Autophagy
Innate immunity
Senescence-associated secretory phenotype
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© 2014 European Association for the Study of the Liver. Published by Elsevier B.V.