Elsevier

Osteoarthritis and Cartilage

Volume 25, Issue 12, December 2017, Pages 1969-1979
Osteoarthritis and Cartilage

A walking program for people with severe knee osteoarthritis did not reduce pain but may have benefits for cardiovascular health: a phase II randomised controlled trial

https://doi.org/10.1016/j.joca.2016.12.017Get rights and content
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Summary

Objective

The primary aim was to evaluate the effect of a dosed walking program on knee pain for patients with severe knee osteoarthritis (OA). Secondary aims evaluated the effects on cardiovascular health, function and quality of life.

Design

Participants with severe knee OA and increased cardiovascular risk were randomly assigned to a 12-week walking program of 70 min/week of at least moderate intensity, or to usual care. The primary outcome was knee pain (0–10). Secondary outcomes were of cardiovascular risk including physical activity, blood pressure, blood lipid and glucose levels, body mass index and waist circumference; WOMAC Index scores; physical function; and quality of life.

Results

Forty-six participants (23 each group) were recruited. Sixteen participants (70%) adhered to the walking program. Intention to treat analysis showed no between-group difference in knee pain. The walking group had increased odds of achieving a healthy systolic blood pressure (OR = 5.7, 95% CI 1.2–26.9), and a faster walking speed (Mean Difference (MD) = 0.12 m/s, 95% CI 0.02–0.23). Per protocol analysis based on participant adherence showed the walking group had more daily steps (MD = 1345 steps, 95% CI 365–2325); more time walking (MD = 18 min/day, 95% CI 5–31); reduced waist circumference (MD = −5.3 cm, 95% CI −10.5 to −0.03); and increased knee stiffness (MD = 0.9 units, 95% CI 0.07–1.8).

Conclusions

Patients with severe knee OA prescribed a 12-week walking program of 70 min/week may have had cardiovascular benefits without decreasing knee pain.

Australian New Zealand Clinical Trials Registry ACTRN12615000015549.

Keywords

Knee osteoarthritis
Physical activity
Cardiovascular health

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