Scientific articleIntraoral Minor Salivary Gland Neoplasms: Review of 213 Cases
Section snippets
Materials and Methods
Two hundred eight cases from the Oral Pathology Service of Oregon Health and Science University (1964–2001) and 5 cases from the Oral Pathology Service of the University of Pennsylvania (1995–1999) were retrospectively studied. Hematoxylin and eosin-stained slides were examined in all cases. Special stains including Masson’s trichrome, mucicarmine, PAS (with and/or without digestion), and immunohistochemical stains for keratin, vimentin, muscle specific actin, S-100 protein, and desmin were
Results
One hundred nineteen MSGTs were benign (56%) and 94 were malignant (44%) (Table 1). The most common tumor overall was pleomorphic adenoma (PA), followed by mucoepidermoid carcinoma (MEC) (Table 2).
PA was the most common benign tumor (93 of 119) (78.2%). PAs occurred between ages 17 and 88 years (average age, 46 years). PAs in females (61 cases) were more common than in males (32 cases) with a ratio of 1.9:1. The location of occurrence of PAs is listed in Table 3. The diverse microscopic pattern
Discussion
Epithelial neoplasms arising in minor salivary glands are relatively common, and they are regularly encountered in oral and maxillofacial surgical pathology services. They are a microscopically heterogeneous group of neoplasms, and some types have a propensity to develop in particular intraoral locations.
There have been several relatively recent reports of significantly large series of these tumors, including Eveson and Cawson’s series of 336 tumors reported in 1985,3 Waldron et al’s series of
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