Basic and patient-oriented researchFelypressin, but Not Epinephrine, Reduces Myocardial Oxygen Tension After an Injection of Dental Local Anesthetic Solution at Routine Doses
Section snippets
Materials and Methods
All animals received humane care in accordance with the Guidelines for the Treatment of Experimental Animals approved by Tokyo Dental College, Chiba, Japan. Male Japanese White rabbits weighing 2.3 to 2.7 kg were purchased from SLC (Tokyo, Japan). Six rabbits received an intramuscular injection of 2% lidocaine hydrochloride solution containing 1:80,000 Epi (Xylesthesin A; 3M Health Care, Tokyo, Japan) at doses of 0.18 mL (E2 group), 0.36 mL (E4 group), and 0.72 mL (E8 group) into the tongue
Results
HR decreased in the F2, F4, and F8 groups. Systolic blood pressure (SBP) increased in the E4 and E8 groups in a dose-dependent manner. Diastolic blood pressure (DBP) increased in the E4, E8, F4, and F8 groups. Mean arterial pressure increased in the E4 and E8 groups. AoF increased in the E4 and E8 groups in a dose-dependent manner. In contrast, AoF decreased in the F2, F4, and F8 groups in a dose-dependent manner (Table 1).
MBF increased in the E2, E4, and E8 groups in a dose-dependent manner.
Discussion
In the present study, 0.18, 0.36, and 0.72 mL of local anesthetic solutions were injected in the rabbit tongue muscle. These doses were equivalent to 2, 4, and 8 cartridges of a dental local anesthetic solution in humans weighing 50 kg by body weight correction. Two cartridges of a dental local anesthetic solution are frequently used in routine dental practices. In addition, 4 to 8 cartridges are possibly used in oral surgery such as in dental implantation or periodontal surgeries. Therefore,
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This study was partly supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan.