PathologyAge-Based Treatment of Aggressive Fibromatosis in the Head and Neck Region
Section snippets
Patients and Methods
A retrospective chart review was performed to identify all patients with a diagnosis of AF of the head and neck region treated at the Department of Oral and Maxillofacial Surgery, Fourth Military Medical University School of Stomatology from January 1, 2008 to December 31, 2012. The patients were identified from the institutional pathology database. A senior pathologist reviewed the original histopathologic reports and tumor specimens to confirm the diagnosis of AF. The clinical data of all the
Results
Of the 5 children, 4 had a microscopically incomplete resection and 1 (patient 7), with a deeply infiltrative tumor in the suprahyoid groups of muscles, had macroscopic residual tumor. All 5 patients received low-dose chemotherapy after conservative tumor resection. Three patients (patients 1, 3, and 7) experienced mild nausea and vomiting. Patient 1 had moderate neutropenia (grade III), 750 cells/μL after 10 doses. The level had increased to normal after missing 2 doses and was not associated
Discussion
Despite their nonmetastatic nature, desmoid tumors have been classified by the World Health Organization as intermediate grade tumors because of their propensity for locally invasive growth and a tendency toward local recurrence, leading to considerable morbidity and, in rare circumstances, death.29 AF is a rare benign tumor accounting for approximately 0.03% of all neoplasms and 3% of all soft tissue tumors. Of the extra-abdominal fibromatosis, only 12% develop in the head and neck region.30
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Cited by (14)
Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
2021, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Historically, surgical resection with negative margins was considered the standard of care, but complete excision in the head and neck may result in significant morbidity with long-term deleterious cosmetic and functional effects in children [9]. Therefore, conservative surgical management with acceptance of positive surgical margins along with use of chemotherapy, radiotherapy, or other more selective medical management has been increasingly utilized in pediatric patients to preserve form and function [1,9]. Due to the rarity of these lesions, few institutions have extensive experience with desmoid tumors of the head and neck in the pediatric population.
Marginal versus segmental mandibulectomy for pediatric desmoid fibromatosis of the mandible – Two case reports and review of the literature
2018, International Journal of Pediatric OtorhinolaryngologyImaging in Otolaryngology
2018, Imaging in OtolaryngologyDiagnostic Imaging: Head and Neck
2017, Diagnostic Imaging: Head and NeckPediatric desmoid fibromatosis of the parapharyngeal space: A case report and review of literature
2016, American Journal of Otolaryngology - Head and Neck Medicine and SurgeryCitation Excerpt :Preservation of function and avoiding unnecessary morbidity should be given a high priority. Adjuvant radiotherapy or chemotherapy may be valuable in controlling microscopic or macroscopic residual disease [1–3,5]; however, interpretation of data is limited by heterogeneity and rarity of the disease. A 14-month-old male presented with a 1-month history of a rapidly enlarging painless right neck mass, preceded by blunt cervical trauma from a 2-feet fall.
Desmoid tumors in neurosurgery: A review of the literature
2015, Clinical Neurology and NeurosurgeryCitation Excerpt :Friede et al. [15] describe an adult case with a tumor centered on the coronal suture operated upon by professor Yaşargil, but due to fact that it was classified as a fibroma and had a recurrence 11 months postoperatively with a histological transformation considered to be malignant, we do not include this case. Interestingly, common carotid and vertebral angiography in the case of Dolman [7] showed an avascular tumor while in the case of Wang et al. [63] the superficial temporal artery supplied the tumor and underwent preoperative embolization. While the head and neck region is a predilection site for extra-abdominal DTs, reported to constitute 6% to 15% of all DTs [1,34], we found only 16 cases with intracranial extension through the skull base described in the literature.
Drs Wang, Koirala, and Ma contributed equally to the present study.
Conflict of Interest Disclosures: None of the authors reported any disclosures.