Surgical oncology and reconstructionHow Does the Close Surgical Margin Impact Recurrence and Survival When Treating Oral Squamous Cell Carcinoma?
Section snippets
Study Design and Sample
This was a retrospective cohort study approved by the institutional review board. The study sample was derived from a population of patients who presented to Harborview Medical Center or the University of Washington Medical Center in Seattle for evaluation and management of OSCC from July 1, 1995 through July 31, 2012. Patients eligible for study inclusion received no previous treatment for their OSCC, received no prior radiation or chemotherapy, underwent tumor resection as their primary
Characteristics of Patients
In total, 174 patients with OSCC were treated with resective surgery at the University of Washington Medical Center or Harborview Medical Center from July 1995 through July 2012. Of those, 54 met the study's inclusion criteria, resulting in a cohort of 14 female and 40 male patients. The mean age was 60.5 years (standard deviation, 14.3 yr; range, 19 to 85 yr). Seven patients had stage 1 (13%), 18 had stage 2 (33%), 3 had stage 3 (6%), and 26 had stage 4 (48%) disease based on the pathologic
Discussion
The purpose of this study was to examine the association between surgical excision margins of patients with OSCC and outcomes of disease-free survival (absence of locoregional recurrence) and overall survival. The authors hypothesized that a close surgical margin would decrease the likelihood of disease-free survival. The specific aims were 2-fold: 1) define the impact a close surgical margin has on locoregional recurrence and overall survival and 2) identify important prognostic indicators
Acknowledgments
The authors thank Dr Rachael T. Smoot for her work consolidating the cancer cases of the head and neck surgeons.
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Conflict of Interest Disclosures: None of the authors reported any disclosures.