PathologyTopical 5-Fluorouracil is a Novel Targeted Therapy for the Keratocystic Odontogenic Tumor
Section snippets
Study Population and Design
To address the research purpose, the authors designed and implemented an ambispective study of patients treated with topical application of 5-FU vs MC after enucleation and peripheral ostectomy of KOTs. The study population was composed of all patients presenting for evaluation and management of KOTs from 2006 through 2014 at the University of Toronto and Mount Sinai Hospital (Toronto, ON, Canada).
To be included in the study sample, patients had 1) a biopsy-proven KOT (OKC), 2) a complete
Patient Demographics
Thirty-two patients with 32 KOTs were reviewed (41% in women and 59% in men; P > .05). The mean age at diagnosis was 42 years 2 months ± 2.9 years (P > .05). Mandibular lesions accounted for 27 of 32 KOTs, with the remaining 5 found in the maxilla (P > .05). Twenty-one KOTs were treated with enucleation, peripheral ostectomy, and topical application of MC, and 11 KOTs were treated by enucleation, peripheral ostectomy, and topical application of 5% 5-FU cream (Table 2). There were no significant
Discussion
The purpose of this study was to determine the efficacy of using topical 5% 5-FU for the treatment of KOTs. The authors hypothesized that 5-FU would be an effective treatment for KOTs with similar or lower recurrence rates and lower incidence of nerve injury than treatment with conventional application of MC. The authors aimed 1) to determine the incidence of KOT recurrence and inferior alveolar nerve injury when treated with topical 5% 5-FU compared with MC and 2) to evaluate the expression of
Acknowledgment
The authors thank Dr Jing Xu of the Applied Molecular Profiling Laboratory at the Princess Margaret Cancer Centre for her technical assistance.
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This study was supported by a Canadian Association of Oral and Maxillofacial Surgeons Research Grant and the Bertha Rosenstadt Endowment Fund.
Conflict of Interest Disclosures: None of the authors have any relevant financial relationship(s) with a commercial interest.