Original ArticleBone Measurements by Peripheral Quantitative Computed Tomography (pQCT) in Children with Cerebral Palsy
Section snippets
Methods
Participants were recruited from a long-term residential care facility. Two sex- and age-matched (± 6 months) control subjects for each case were randomly selected from an existing database of healthy children obtained from the same geographic region. The protocol was approved by the institutional review boards at South Dakota State University and the University of South Dakota. Informed consent was signed by a parent if the child was not of adult age and also if the child was of adult age but
Results
Means and standard deviations for anthropometric and bone measurements by group and P values from matched-pairs analysis are given in Table. Cortical BMC, cortical area, cortical thickness, periosteal circumference, endosteal circumference, and pSSI differed by group (all P < .05), whereas tibia length and cortical vBMD did not differ. Weight was marginally greater in the control group than in the CP group. Group-by-weight interactions were significant (P ≤ .05) in mixed models for cortical
Discussion
In patients with CP, standard measurements for bone density and geometric bone measurements are limited because of joint contractures, bony deformities from fractures or surgical procedures, metallic implants, positioning confines, and uncontrollable movements that invalidate the scans. pQCT methods are not immune to these challenges. In general, pQCT imaging can be used to measure peripheral bones and obtain trabecular bone measurements at an ultra-distal site while cortical bone measurements
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