Original ArticleAlterations in Ventricular Structure and Function in Obese Adolescents with Nonalcoholic Fatty Liver Disease
Section snippets
Methods
Three groups of adolescents were studied: (1) lean (n = 14); (2) obese (BMI ≥95th percentile for age and sex19) with normal intrahepatic triglyceride (IHTG) content (<5.6% liver volume as triglyceride20; n = 15); and (3) obese with increased IHTG (NAFLD) (≥5.6% liver volume as triglyceride; n = 15). A comprehensive assessment was made of: (1) body composition, including body fat mass, abdominal fat distribution, and ectopic fat (IHTG, intracardiac triglyceride [ICTG], and skeletal muscle
Body Composition
Obese subjects with and without NAFLD were matched on BMI, BMI Z-score, and percent body fat (Table I). Intra-abdominal fat volume and IHTG content were greater in obese subjects with NAFLD than those without NAFLD. Although IHTG content was greater in obese subjects with NAFLD than those without NAFLD, IMTG and ICTG were not different between the 2 groups (Table I). Values for IHTG content correlated positively with percent body fat (r = 0.570, P < .001) and intra-abdominal fat volume (r =
Discussion
The presence of increased IHTG content is an important marker of metabolic dysfunction (multi-organ insulin resistance and dyslipidemia).5, 6 Our data demonstrate that obese adolescents with NAFLD have greater abnormalities in cardiac function, manifested by decreased systolic and diastolic myocardial strain and strain rate than obese adolescents who have normal IHTG content. The cardiac functional abnormalities in our obese adolescents with NAFLD were independent of traditional cardiac risk
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