Original ArticleIncrease in the Incidence of Differentiated Thyroid Carcinoma in Children, Adolescents, and Young Adults: A Population-Based Study
Section snippets
Methods
We selected cases of differentiated thyroid cancer diagnosed between 1984 and 2010 in patients <30 years of age from the National Cancer Institute's SEER 9 cancer registry (SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2012 Sub [1973-2010] <Katrina/Rita Population Adjustment> - Linked To County Attributes - Total US, 1969-2011 Counties, National Cancer Institute, Division of Cancer Control and Population Sciences, Surveillance Research Program, Surveillance Systems Branch,
Results
Our series consisted of 6065 patients (5101 women) up to 29 years of age with differentiated thyroid carcinoma; 83.9% of cases occurred in white patients, and 96.8% occurred in adolescents and young adults (Table I). As reported in adult studies, incidence was lower in black patients (5.89 per million people vs 18.83 in white subjects). Tumors measuring 2.0 cm or more accounted for more than 50% of all tumors diagnosed in all age groups. There was an association between tumor size and age;
Discussion
Studies have shown an increase in the incidence of thyroid carcinoma in recent decades15, 16, 17, 18, 19, 20, 21; this increase does not appear to be geographically dependent.19 In this study we sought to investigate whether those same trends are seen at younger age through a population-based analysis encompassing the pediatric and older age groups. Although no changes in incidence trends were seen in children, similar trends seen in adults are occurring in adolescents and young adults.
To
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L.V. was recipient of a scholarship from the program “Pesquisadores do Futuro”- Faculty of Medicine Sciences of Santa Casa of São Paulo, Brazil. The authors declare no conflicts of interest.