The Journal of Steroid Biochemistry and Molecular Biology
ReviewPredictors of serum 25(Oh)D increase following bimonthly supplementation with 100,000 IU vitamin D in healthy, men aged 25–65 years
Introduction
The relationship between vitamin D intake and the increase in serum 25(OH)D levels is often inconsistent and is influenced by factors such as seasonality, age, ethnicity, BMI, physical activity and genetic factors [1], [2], [3], [4]. Although the rise in serum 25(OH)D levels following standard vitamin D supplementation varies between individuals, the recommended dosage is the same for everyone, regardless of individual characteristics. Thus, understanding the predictors of the serum 25(OH)D response is needed to determine which factors may influence the status of 25(OH)D. The study aims to determine personal and environmental predictors for the response of 25(OH)D to vitamin D treatment as demonstrated in healthy young men.
Section snippets
Subjects and methods
Predictors for increase in serum 25(OH)D were evaluated in a 12-month vitamin D supplementation trial of healthy men (aged 25–65) with serum 25 (OH) D < 20 ng/ml. Participants were recruited during their annual periodic examinations at the Rambam Medical Center in Haifa, Israel, and via the study's website. The study was approved by the Rambam Health Care Campus review board and registered in ClinicalTrials.gov as NCT01016184 and funded by a grant from The Preventive Action, Safety & Health
Results
The range of baseline serum 25(OH)D levels was 4.0–19.8 ng/ml with a mean increase of 10.18 ± 5.46 ng/ml after 12 months. 29.1% (n = 23) of the participants had BMI < 25 kg/m 53.2%n = 42) had BMI 25–30 kg/m2 and 17.7% (n = 14) had BMI ≥ 30 kg/m2 There was a significant difference in lipid levels and age across BMI categories (Table 1). Overall serum 25(OH)D levels were associated with seasons (p = 0.024), such that significantly lower levels were found in the winter than in the autumn (p = 0.017) (data not shown).
Discussion
We showed that BMI is the most powerful predictor for the increase in serum 25(OH)D levels following vitamin D supplementation among generally healthy men. Our findings are in accord with those of Gallagher et al., who showed that BMI is the strongest predictor for the increase in 25(OH)D levels following vitamin D supplementation in healthy postmenopausal women [8]. Similar findings were shown in the Tromsø study among men and women aged 56.7 ± 9.2 years [9], among the elderly [10], and in
References (14)
- et al.
Changes in vitamin D supplement use and baseline plasma 25-hydroxyvitamin D concentration predict 5-y change in concentration in postmenopausal women
J. Nutr.
(2012) Vitamin D importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
Am. J. Clin. Nutr.
(2004)- et al.
Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index
Am. J. Med.
(2009) - et al.
Factors predicting vitamin D response variation in non-Hispanic white postmenopausal women
J. Clin. Endocrinol. Metab.
(2012) - et al.
Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study
Am. J. Epidemiol.
(2010) - et al.
Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient
J. Steroid Biochem. Mol. Biol.
(2013) - et al.
A randomized controlled trial of vitamin D3 supplementation in African American women
Arch. Intern. Med.
(2005)