Case reportTransplantation of tissue-engineered cartilage for the treatment of osteochondritis dissecans in the elbow: Outcomes over a four-year follow-up in two patients
Section snippets
Case reports
We obtained Institutional Review Board Approval of Hokkaido University School of Medicine for the present treatment protocol (04018).
Discussion
To our knowledge, only a few patients with elbow OCD lesions treated with ACI have been reported in the English literature.17, 28 Although these reports showed favorable outcomes of this procedure, the results were based on short-term follow-up. Therefore, the effectiveness of this procedure might be achieved not by cartilage resurfacing, but by removal of an osteochondral fragment. The current patients with advanced OCD lesion demonstrated excellent ACI results at 52 and 57 months
Conclusions
The current postoperative results indicate that performing collagen-hydrogel based ACI for OCD lesions in the elbow provides satisfactory outcomes over a follow-up of 4 years. However, recent prospective, comparative, clinical trials have shown no significant superiority of ACIs over other surgical procedures for the repair of osteochondral defects in the knee.2, 13, 20 In addition, this procedure might lead to degenerative changes in the grafted and adjacent cartilage. Therefore, a long-term
Acknowledgments
The authors thank Prof Mitsuo Ochi, Department of Orthopaedic Surgery, Hiroshima University School of Medicine, for his advice on the operative technique. We received technical support on cell cultivation from a collaborator at Japan Tissue Engineering Co, Ltd.
Disclaimer
The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article.
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