Original ArticleIs Neutrophil/Lymphocyte Ratio Predict to Short-term Mortality in Acute Cerebral Infarct Independently from Infarct Volume?
Section snippets
Study Population
This study is a hospital-based retrospective investigation. A total of 655 patients with AIS more than 18 years of age who were admitted to Meram Medical School Hospital were screened between October 2007 and March 2013, and patients with a diagnosis of AIS in the first day were included in the study. The study protocol was approved by the local ethics committee.
Exclusion criteria for the patients were the following: (1) those who were admitted to the hospital 24 hours after AIS; (2) those with
Results
The mean age of 151 patients who were diagnosed with supratentorial AIS was 69.37 ± 13.96 years. The mortality rate was 13.2% (n = 20) by 30-day follow-up. Demographic and laboratory findings of survived and nonsurvived patients are reported in Table 1. Both NLR on admission to the hospital and infarct volume of nonsurvived group were significantly higher than survived group (P < .05). Also there were significant differences in terms of GCS, NIHSS, age, serum glucose, and so forth (Table 1).
The
Discussion
In recent literature, it is reported that the high NLR ratios in both acute coronary syndromes and AIS might be related with the vascular inflammation reaction8, 9; also the formed acute inflammation can affect the size of the infarct, which can be followed up with peripheral inflammatory parameters of acute inflammation.3, 7, 10 In our study, positive correlations between infarct volume with NLR and increased NLR ratios in the high infarct volume have been detected. Regression analyses have
Conclusion
NLR on admission to the hospital was a predictor of short-term mortality independent from infarct volume in patients with first AIS. Changing blood cell composition during acute ischemic stroke maybe more important than current knowledge. Thanks to the routine usage and inexpensive nature of hemogram analysis, NLR maybe a new research area for prospective trials in patients with AIS.
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