Original ArticleAssociation of Stroke Clinical Outcomes with Coexistence of Hyperglycemia and Biomarkers of Inflammation
Section snippets
Study Participants
All patients with a clinical diagnosis of AIS admitted to the 4 hospitals in Shandong from January 1, 2006, to December 31, 2008, were potentially eligible for the study. Among 2868 AIS patients admitted to the 4 hospitals during the study period, 2675 had a computed tomography (CT) scan or magnetic resonance imaging (MRI) confirmed ischemic stroke and were included in this analysis. A total of 193 patients were excluded from our analysis because of lack of a CT scan, MRI test, National
Results
A total of 2675 ischemic stroke patients were included in our analysis, there were 2228 patients without study outcomes and 447 patients with study outcomes (19 death and 428 patients with NIHSS ≥5). The median time from onset of symptom to admission was 39.5 hours, and the median duration of hospitalization was 15 days.
Table 1 presents the demographic and clinical characteristics of AIS patients on admission by study outcomes. Those with study outcomes were more likely to have
Discussion
The results of our retrospective study among AIS patients indicated that hyperglycemia and increased levels of inflammation biomarkers such as WBC count, NEUR, ESR, and their coexistences on admission were positively and significantly associated with study outcomes. Patients with higher levels of WBC count, NEUR, and ESR and their coexistences with hyperglycemia were all at a significantly higher risk for the outcomes than those with normoglycaemia and without any elevated biomarkers. In
Acknowledgments
This study is supported by Youth Found of the National Natural Science Foundation of China (grant no. 81102190), Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases and a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions, China.
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The authors have no conflicts of interest to disclose.