Clinical studyCorrelation between Tumor Perfusion and Lipiodol Deposition in Hepatocellular Carcinoma after Transarterial Chemoembolization
Section snippets
Patients
This prospective study was approved by our Institutional Review Board, and patient informed consent was waived. From June 2006 to May 2008, 24 patients with unresectable HCC proven by biopsy were admitted to our hospital. Of the 24 patients, 20 were men and 4 were women, with an average age of 51.6 ± 10.2 years (range, 28–70 years). All of the 24 patients had chronic viral hepatitis B infection and liver cirrhosis. The mean value of the Child-Pugh score of the 24 patients was 6.2 ± 1.6 points.
Results
All of the analyzed tumors have the typical arterial enhancement and portal venous washout characteristics on multiphase CT imaging.
Before chemoembolization, the CT perfusion parameters of the tumors were calculated (Table 2), and quantitative maps were created in all 24 patients. All patients had good ratings of perfusion acquisition. Four weeks after chemoembolization, the diameter of the tumors on the CT images was 9.0 ± 5.4 cm, which did not significantly change when compared with that
Discussion
CT perfusion imaging is a new application for the quantification of tissue perfusion using dynamic CT scanning, which is performed after intravenous bolus administration of an iodinated contrast agent. This technique can quantify perfusion in absolute units and at high spatial resolution (7, 8, 15).
In this study, we studied liver tumor perfusion with CT perfusion imaging, and we investigated the correlation between tumor perfusion and lipiodol deposition in the tumor tissue after
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2020, Journal of Vascular and Interventional RadiologyCitation Excerpt :According to the literature describing the VX2 hepatoma model (18), the viable portion of a VX2 tumor has an approximately 2 times higher blood volume and a 3 times higher arterial enhancement fraction compared with the same volume of a normal liver. Therefore, this study assumed that chemoemulsion infused at the proper hepatic artery is accumulated in the viable portion of a VX2 tumor 6 times higher than the same volume of a normal liver (8,19). Hence, the required iodine and iodized oil amounts to achieve a pathologic CR were calculated according to the equations in Appendix A (available online on the article’s Supplemental Material page at www.jvir.org) (20).
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2015, Clinical RadiologyCitation Excerpt :Of these 73 patients, 52 (71.23%) had cirrhosis caused by hepatitis B virus (HBV) infection. The lipiodol deposition in the tumour after chemoembolization was divided into three grades.22 Grade I was defined as the iodized oil remaining and dispersing throughout the tumour or the area of iodized oil deposition was ≥60% of the tumour (n = 25).
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2012, European Journal of RadiologyCitation Excerpt :An accurate non-invasive in vivo method for the evaluation of tumor angiogenesis would be highly desirable. Perfusion CT allows for the quantitative assessment of tumor angiogenesis according to multiple functionally relevant parameters including hepatic blood flow (HBF), hepatic blood volume (HBV), and permeability of capillary vessel surface (PS); each of these parameters have shown strong correlation with tumor angiogenesis reflected by MVD measurements in experimental and clinical studies [4,5]. However, perfusion CT of the liver has been of only limited use in clinical practice owing to increased radiation exposure and poor image quality caused by the use of low tube voltage [5,6].
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None of the authors have identified a conflict of interest.