Brief reportPercutaneous Irreversible Electroporation of Surgically Unresectable Pancreatic Cancer: A Case Report
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Case Report
A 76-year-old African American male diagnosed with stage III (tumor/node/metastasis stages T4N0M0) unresectable pancreatic cancer secondary to vascular invasion was referred for percutaneous IRE after he refused chemotherapy or radiation. Computed tomography (CT) imaging (Fig 1) revealed a 4.1 × 4.1 × 3.5-cm mass with encasement of the celiac axis and origin of the superior mesenteric artery and occlusion of the extrahepatic portal vein and superior mesenteric vein. A whole-body staging CT scan
Discussion
Pancreatic cancer was newly diagnosed in more than 40,000 patients in 2010, with 30% of patients presenting with surgically unresectable disease without metastatic disease (14). Primary therapeutic modalities for stage III pancreatic carcinoma are chemotherapy and radiation. The present report of successful ablation of locally advanced pancreatic cancer suggests that IRE may have a role in this location for local tumor control.
Encouraging results have also been reported with thermal ablation of
References (14)
- et al.
Radiofrequency ablation in pancreatic cancer
HPB (Oxford)
(2006) - et al.
Irreversible electroporation of the pancreas in swine: a pilot study
HPB (Oxford)
(2010) - et al.
Investigation of the safety of irreversible electroporation in humans
J Vasc Interv Radiol
(2011) Medical device databases [updated 2011 Sept 10]510K premarket notification for low energy direct current thermal ablation system K080202
(2010)- et al.
Tissue ablation with irreversible electroporation
Ann Biomed Eng
(2005) - et al.
Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation
Technol Cancer Res Treat
(2007) - et al.
The effect of irreversible electroporation on blood vessels
Technol Cancer Res Treat
(2007)
Cited by (71)
Electroporation combined with intelligent drug delivery promising new and clean approach to cancer treatment
2023, Results in EngineeringA prospective, multi-institution assessment of irreversible electroporation for treatment of locally advanced pancreatic adenocarcinoma: initial outcomes from the AHPBA pancreatic registry
2019, HPBCitation Excerpt :This finding is consistent with previously-reported mortality rates between 0 and 2% regardless of surgical (open vs percutaneous) approach.11,23,25–27 With respect to morbidity, the present study, which demonstrates an overall adverse event rate of 18% overall and a severe (≥grade 3) adverse event rate of 13%, compares favorably with previous work reporting complication rates between 0 and 53%.7,9,10,18,23,28 As a result, it highlights the importance of a standardized IRE protocol for broad minimization of morbidity following the procedure.
Noninvasive detection of changes in cells’ cytosol conductivity by combining dielectrophoresis with optical tweezers
2018, Analytica Chimica ActaCitation Excerpt :It is used in electrochemotherapy [10,11,12] and as a non-viral method of in vitro and in vivo gene delivery to cells (gene electrotransfer) [7,13]. Furthermore, electroporation as a stand-alone technique can be used for tumor ablation using the non-thermal irreversible electroporation [10,12,14–19]. In spite of its important applications, the cellular mechanisms of the electrically-induced increase in membrane permeability are still under debate, demanding detection of changes in cellular electrical properties during the electroporation process [20].
Percutaneous irreversible electroporation for treatment of locally advanced pancreatic cancer following chemotherapy or radiochemotherapy
2016, European Journal of Surgical OncologyCitation Excerpt :With thermal ablation, there is also a risk that heat close to the vessels is insufficient to ablate all tumor cells, the so called heat-sink effect, especially since LAPC per definition include major vessels.4 Irreversible electroporation (IRE) is a non-thermal based ablation technique and is based on the transmission of short direct current pulses through the tumor via needles, leading to irreversible change in cell membrane integrity and subsequent apoptosis.5–9 A unique feature of IRE is that although some heat is generated collagen structures such as blood vessels and bile ducts are not destroyed.
Multi-parameter Effect Analysis and Large Living Animal Experimental Study of Synergistic Pulse-enhanced Irreversible Electroporation Ablation
2023, Gaodianya Jishu/High Voltage Engineering
This work was supported by the research department at the Inova Alexandria Hospital Cardiovascular and Interventional Radiology Department. Neither of the authors has identified a conflict of interest.