Clinical StudyComparative Study of Percutaneous Transhepatic Biliary Stent Placement with or without Iodine-125 Seeds for Treating Patients with Malignant Biliary Obstruction
Section snippets
Materials and Methods
This prospective study was approved by the ethical committee of our hospital and was registered as a Chinese clinical trial (registration no. ChiCTR-TRC-11001456), for which each patient provided written informed consent.
Results
The stents combined with 125I seed strand were implanted in the malignant biliary obstruction of 28 patients (group A), and the remaining 27 patients were implanted with stents only (group B). Mean 15.46 ± 2.30 (range, 9–18) 125I seeds were implanted in each patient (Table 3). The technical success rate of stent placement was 100% in all patients. None of the 125I seeds were lost during the delivery and deployment process. Combined single photon emission computed tomography/CT scan performed 1
Discussion
Despite progress in diagnostic and therapeutic options made in recent decades, the prognosis for patients with MOJ remains poor. The current treatment options for MOJ include surgery, interventional therapy with biliary stent placement, and endoscopic therapy. Although surgery can relieve jaundice in addition to removing lesions and peripheral vascular invasion (17), biliary stent placement is the preferred treatment for patients with MOJ who have unresectable tumors or who are unwilling to
Acknowledgments
We thank Dr. Shayahati Bieerkehazhi (Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas) for editing our manuscript.
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A stent with radioactive seed strand insertion for inoperable malignant biliary obstruction: A meta-analysis
2021, BrachytherapyCitation Excerpt :We initially identified 196 potentially relevant studies, of which nine studies were selected in this meta-analysis (Fig. 1). Of these studies, three were RCTs (10, 12, 13) and six were retrospective analyses (11, 14–18). In total, these studies included 643 patients with MBO (280 and 363 who underwent stent insertion with and without RSS insertion, respectively) (Table 1).
An iodine-125 seed strand combined with a metal stent versus a metal stent alone for obstructive jaundice caused by pancreatic ductal adenocarcinoma
2021, BrachytherapyCitation Excerpt :It has demonstrated that the biliary stent loaded with 125I seeds can offer a significant improvement in swallowing function and increased stent patency for patients with MOJ compared with stent placement alone (12, 20–23). For instance, some studies (13–15, 20, 22, 24–32) showed that an 125I seed strand combined with a metal stent prolonged stent patency and decreased reinterventions compared with a metal stent in MOJ. However, these studies included patients with MOJ caused by cholangiocarcinoma, PDAC, and metastatic cancer or analyzed the efficacy of an 125I seed strand combined with a metal stent only (14, 15, 28–32) without comparing with a metal stent.
No Advantage of Expanded Polytetrafluoroethylene and Fluorinated Ethylene Propylene–Covered Stents over Uncovered Nitinol Stents for Percutaneous Palliation of Malignant Infrahilar Biliary Obstruction: Results of a Single-Center Prospective Randomized Trial
2020, Journal of Vascular and Interventional RadiologyCitation Excerpt :The decision for stent placement should be based on patient condition and the prospect of chemotherapy. Whether drug-eluting stents or stents combined with locoregional therapy (eg, radiofrequency ablation, brachytherapy) will significantly improve patency and hence the odds for chemotherapy is still to be answered (30–32). It might be that novel endoscopic US-guided techniques will seriously challenge the percutaneous approach, but the endoscopists will also have to find a solution for the covered stent dysfunctions described (33,34).
The efficacy and safety of <sup>125</sup>I seeds combined with biliary stent placement versus stent placement alone for malignant biliary obstruction: a systematic review and meta-analysis
2023, Quantitative Imaging in Medicine and Surgery
None of the authors have identified a conflict of interest.
A.H. and J.-P.G. contributed equally to this article.