Phase I study of the HER3-targeted antibody patritumab (U3-1287) combined with erlotinib in Japanese patients with non-small cell lung cancer☆
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Abbreviations
HER
human epidermal growth factor receptor
NSCLC
non-small cell lung cancer
DLT
dose-limiting toxicity
MTD
maximum tolerated dose
EGFR-TKI
epidermal growth factor receptor-tyrosine kinase inhibitor
RECIST
response evaluation criteria in solid tumors
ECOG
Eastern Cooperative Oncology Group
CTCAE
Common Terminology Criteria for Adverse Events
AE
adverse events
ELISA
enzyme-linked immunosorbent assay
AUC
area under the curve
DCR
disease control rate
ORR
overall response rate
PR
partial response
SD
stable disease
PD
progressive disease
Keywords
Patritumab
Erlotinib
Human epidermal growth factor receptor (HER3)
Non-small cell lung cancer
Gefitinib failure
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ClinicalTrials.jp Identifier: JapicCTI-111506.
Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.