Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials
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Cited by (42)
What has neurophysiology revealed about migraine and chronic migraine?
2023, Handbook of Clinical NeurologyThe effects of neonatal maternal deprivation and chronic unpredictable stresses on migraine-like behaviors in adult rats
2022, Neuroscience LettersCitation Excerpt :In patients who suffer from migraine without aura, orally administered NTG exhibited a significant heat pain threshold reduction. The patients experienced a slight headache immediately after NTG intake and a moderate or severe subsequent headache accompanied by non-headache symptoms like nausea, vomiting, and photophobia [11]. In line with previous studies, our data shows that female rats manifest more severe NTG-induced migraine symptoms.
Gut microbiota and migraine
2022, Neurobiology of PainCitation Excerpt :Nitroglycerin (NTG) treatment in rodents has been used to model migraine after it was found clinically that a large percentage of patients being treated with nitrile drugs experience headache. The NTG model shares important features with what is seen in human migraine patients such as shared pain behaviors, central sensitization, and cortical spreading depression (de Tommaso et al. 2004; Knapp et al. 2017; Long et al. 2020). Rodent models employing single and chronic administration of NTG show both facial and hindpaw hypersensitivities as well as photophobia (Anapindi et al. 2019; Bates et al. 2010; Casili et al. 2020; Farajdokht et al. 2017; Farkas et al. 2016; Guo et al. 2021; Moye et al. 2019; Pan et al. 2022; Shu et al. 2020; Tang et al. 2018; Zhang et al. 2020a).
Nitric oxide role in anxiety-like behavior, memory and cognitive impairments in animal model of chronic migraine
2020, HeliyonCitation Excerpt :NO is an important neurotransmitter in pain pathways and it is considered to play a fundamental role in migraine pathophysiology [7]. It has been demonstrated that the administration of nitroglycerin (NTG) as a nitric oxide donor induces a headache in healthy subjects and more severe delayed headache in migraineurs [8]. A lower cognitive performance has been reported in painful conditions [9].
Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats
2020, NeuropharmacologyCitation Excerpt :The above pathway may promote the release of pro-nociceptive and pro-inflammatory mediators in both spinal and trigeminal nerves leading to peripheral and central sensitization. Consequently, an enhanced sensitivity for pain can be seen in migraine sufferers (de Tommaso et al., 2002, 2004). Orexin-A (OrxA) is produced by a small number of neurons in the lateral and posterior hypothalamic regions.