Extrapyramidal symptoms in Frontotemporal Dementia: Prevalence and clinical correlations
Section snippets
Acknowledgements
We thank patients and their families for the time and effort they have dedicated to our research. The authors are indebted to Marina Zanetti for valuable help in the neuropsychological assessment. This work was supported by PRIN Ministry of Research 2005 to BB, and by MURST 60% 2005–2006 to BB and AP.
References (13)
- et al.
The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia
Neurology
(1994) - et al.(1987)
- et al.
Clinicopathological correlates in frontotemporal dementia
Ann. Neurol.
(2004) - et al.
The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia
JINS
(2000) Pick's complex and FTDP-17
Mov. Disord.
(2003)- et al.
Assessment of older people: self-maintaining and instrumental activities of daily living
The Gerontologist
(1969)
Cited by (38)
Cognitive Impairment in Older Adults: Epidemiology, Diagnosis, and Treatment
2022, Psychiatric Clinics of North AmericaCitation Excerpt :Behavioral symptoms include social disinhibition, apathy, abulia, loss of empathy, emotional blunting, perseverative, stereotyped or compulsive behavior, hyperorality, and dietary changes.33,55 It is important to especially assess for features of motor neuron disease and/or extrapyramidal deficits, as Parkinsonian features are seen in 25%–80% of FTD cases with the most common symptoms being bradykinesia, parkinsonian gait, and rigidity.56–58 International consensus on diagnostic criteria for bvFTD requires imaging results consistent with frontal and/or anterior temporal atrophy on MRI or CT, or frontal and/or anterior temporal hypoperfusion or hypometabolism on PET or single-photon emission computerized tomography (SPECT) for a diagnosis of probable bvFTD.55
Isolated parkinsonism is an atypical presentation of GRN and C9orf72 gene mutations
2020, Parkinsonism and Related DisordersFalls in frontotemporal dementia and related syndromes
2018, Handbook of Clinical NeurologyCitation Excerpt :For example, in one study 71% of 31 bvFTD patents were reported to have a “parkinsonian” gait or posture, as detected by the United Parkinson's Disease Rating Scale (Diehl-Schmid et al., 2007). In contrast, only 22.7% of 75 bvFTD patients in another study had any feature of parkinsonism, with bradykinesia and rigidity being most common (Padovani et al., 2007), and the prevalence of gait disturbance or falls was not specifically reported. A third study of a clinical cohort reported parkinsonism in 22% of FTD patients (Kertesz et al., 2011), but again the precise rate of falls was not reported.
Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes
2017, Journal of the Neurological SciencesCitation Excerpt :In bvFTD patients, parkinsonism was observed in 22.7%, and cognitive performances were not affected by the presence of parkinsonism [14]. On the other hand, psychotic features were more prominent and instrumental ADL was more impaired in bvFTD patients with parkinsonism than in those without [14]. In PPA patients, nfvPPA patients showed more parkinsonian features than logopenic PPA patients [15].
Epidemiology and genetics of frontotemporal dementia: A door-to-door survey in Southern Italy
2012, Neurobiology of AgingRecent Advances in Frontotemporal Dementia
2023, Canadian Journal of Neurological Sciences