Elsevier

Neuroscience Letters

Volume 458, Issue 2, 17 July 2009, Pages 84-88
Neuroscience Letters

β1-Adrenoceptor distribution in the rat brain: An immunohistochemical study

https://doi.org/10.1016/j.neulet.2009.04.023Get rights and content

Abstract

Current knowledge of the central nervous system distribution of the β1-adrenergic receptors (β1-AR) is incomplete. Here we present a general map of the β1-AR distribution in the rat brain. β1-AR-immunoreactivity was detected throughout the entire rat brain, but particularly dense staining was observed in the cerebellar cortex and basal ganglia. Brainstem areas displaying significant β1-AR-immunoreactivity include the ventrolateral medulla, nucleus ambiguus and the nucleus of the solitary tract. Within the hypothalamus, only the paraventricular nucleus and the median eminence (ME) showed β1-AR immunostaining. Numerous β1-AR-immunoreactive cells were also found in the hippocampus, basal ganglia and cerebral cortex. These results extend our knowledge of the expression profile of β1-AR in the central nervous system. The identification of several distinct β1-AR immunoreactive substrates linked with neuropathophysiological roles in cardiovascular disease supports the hypothesis that the therapeutic benefit of β1-AR blockade may be conferred at least in part through central nervous system mechanisms.

References (30)

  • A. Wanaka et al.

    Immunocytochemical localization of β-adrenergic receptors in the rat brain

    Brain Res.

    (1989)
  • M.R. Bristow

    β-Adrenergic receptor blockade in chronic heart failure

    Circulation

    (2000)
  • W.C. Drevets et al.

    Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

    Brain Struct. Funct.

    (2008)
  • M. Esler et al.

    Overflow of catecholamine neurotransmitters to the circulation: source, fate and functions

    Physiol. Rev.

    (1990)
  • F.M. Gengo et al.

    Lipid-soluble and water-soluble beta-blockers. Comparison of the central nervous system depressant effect

    Arch. Intern. Med.

    (1987)
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