Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors
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Biometals in Autism Spectrum Disorders
2020, Biometals in Autism Spectrum DisordersSensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice
2018, Pharmacological ReportsCitation Excerpt :Behavioral experiments were performed between 9:00 a.m. and 8:00 p.m. Acoustic startle responses were measured in a startle chamber (SR-LAB; San Diego Instruments, San Diego, CA, USA) as previously described with a little modification [27]. In the demonstration of PPI of the acoustic startle reflex, subjects were presented with a series of discrete trials comprising of a mixture of four types of trials.
Significance of synaptic Zn<sup>2+</sup> signaling in zincergic and non-zincergic synapses in the hippocampus in cognition
2016, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :Metallothioneins are involved in the regulation of the transport, storage and transfer of Zn2+ to various enzymes and transcription factors [87,88]. The role of metallothioneins in the regulation of intracellular Zn2+ homeostasis suggests that metallothioneins are involved in hippocampus-dependent memory, although disruption of the metallothionein-III gene exhibits normal spatial learning [89], while exhibiting abnormalities of psychological behaviors [90]. Aging is the process associated with progressive pathophysiological features such as oxidative stress, altered cell metabolism, damaged nucleic acid, and deposition of abnormal forms of proteins.
Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary-adrenal (HPA) axis
2014, Neurochemistry InternationalCitation Excerpt :The behavior of young and aged MT-3 deficient mice in the EPM shows a similar pattern to that of the wild-type one. Effects of MT-3 on activity and anxiety have been reported by some authors, and most studies report no differences among MT-3 KO mice compared to their controls (Erickson et al., 1997; Koumura et al., 2009). Since MT-3 is most abundant in neurons of hippocampus and dentate gyrus, it is conceivable that its absence might impair hippocampal-dependent processes, mainly because MT-3 could be involved in regulation of brain zinc.
Hair zinc levels and psychosis risk among adolescents
2022, Schizophrenia
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These authors contributed equally to this work.