A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor
Research highlights
▶ High-fat diet decreases neural progenitor cells proliferation and hippocampal neurogenesis. ▶ High-fat diet increases lipid peroxidation and decreases BDNF in hippocampus. ▶ BDNF protects neural progenitor cells proliferation against lipid peroxidation.
Section snippets
Acknowledgments
This research was supported by the Basic Science Research Program though the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (no. 2009-0067079). The authors thank Dr. Cepko at Harvard University, USA for providing the C17.2 cells.
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