Neuron
Volume 91, Issue 3, 3 August 2016, Pages 644-651
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Article
Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits

https://doi.org/10.1016/j.neuron.2016.06.036Get rights and content
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Highlights

  • IL- and PL-projecting BLA PNs receive uniform inhibition from CB1R+ CCKL interneurons

  • CCKL-PNIL synapses are more susceptible to activity-dependent suppression

  • PNIL display a higher abundance of the endocannabinoid-synthesizing enzyme DGLα

  • Differential DGLα abundance in PNIL and PNPL is stable after fear conditioning

Summary

Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory micro-circuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.

Cited by (0)

3

Present address: Roche Pharmaceutical Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland

4

Co-first author