Cognitive, Behavioral, and Systems NeuroscienceResearch PaperThe coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory
Research Paper
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Highlights
▶The coumarin scopoletin has been described as AChE inhibitor. ▶Now we show it exerts promising procognitive properties via nAChRs. ▶It enhances release of ACh and potentiates hippocampal LTP. ▶It improves novel object recognition and T-maze alternation in scopolamine-amnestic mice and ameliorates object memory in age-impaired mice.
Key words
ACh release
long-term potentiation
hippocampus slice
nicotinic acetylcholine receptor
T-maze
object recognition
Abbreviations
ACh
acetylcholine
AChE
acetylcholinesterase
AD
Alzheimer's dementia
AP-5
d,l-2-amino-5-phosphonopentanoic acid
CSF
cerebrospinal fluid
DHE
dihydro-β-erythroidine
DMSO
dimethyl sulfoxide
fEPSPs
field excitatory postsynaptic potentials
HFS
high-frequency stimulation
LTP
long-term potentiation
MAO
monoamino oxidase
MEC
mecamylamine
nAChR
nicotinic acetylcholine receptor
NMDA
N-methyl-D-aspartate
SCOP
scopolamine
SCT
scopoletin
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These authors contributed equally to this work.
Copyright © 2011 IBRO. Published by Elsevier Ltd.