Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Oral medicineThe efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse
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Materials and Methods
The minocycline dose selected for the present study was equivalent to the accepted therapeutic dose of systemic minocycline (100 mg/day) used for controlling acne vulgaris.18 The study was designed as a randomized, double-blind, crossover study.
Twenty-nine consecutive patients seeking treatment for RAS at the Oral Medicine Clinic at the Sheba Medical Center were enrolled. Healthy patients over 18 years of age with over 4 RAS episodes per year and with no known allergy to minocycline were
Results
Twenty-nine patients with RAS who met the entry criteria were enrolled in the study. Eight patients did not experience any episode of RAS during the study period, and an additional 6 experienced only 1 episode within the time limit of the study. Only 1 patient dropped out of the study because of intolerance of the taste of the mouthwash. A total of 14 patients (8 males, 6 females) completed the 2 arms of the study. The mean age of the eligible patients was 32.5 years (range, 26-61 years). Only
Discussion
The efficacy and safety of aqueous solution of minocycline in the management of symptoms associated with RAS has been established.16, 17 In 2 previous randomized controlled studies, we demonstrated the superiority of minocycline mouthwash over placebo and over tetracycline-based mouthwash in terms of pain intensity and duration.16, 17 The present study demonstrated the superiority of a higher concentration of minocycline (0.5%) over the dosages that were evaluated in our previous studies
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