Oral medicine
The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse

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Objective

The aim of the study was to assess the efficacy of 2 different concentrations of minocycline mouthwashes on the symptoms of recurrent aphthous stomatitis (RAS).

Study Design

The 2-year study was designed as a randomized, double-blind, crossover study. Healthy patients with frequent RAS episodes received 2 sealed and computer-randomized marked kits containing minocycline mouthwashes (0.2% and 0.5% solution). The patients were asked to use 1 of the kits on the first episode of RAS, starting with the first onset of prodromal symptoms, until the symptoms resolved or up to a maximum of 10 days (whichever came first). The patients were asked to use their second kit during a subsequent episode.

Results

A total of 14 patients (8 males, 6 females) completed the 2 arms of the study. The mean intensity of pain was significantly lower when the 0.5% solution was used compared with the 0.2% solution (P = .027). The difference reached the level of statistical significance as soon as the end of the second day of use (P = .032). Only minor and temporary adverse reactions were documented.

Conclusions

We found that 0.5% minocycline mouth rinse was more effective than the 0.2% concentration, which had been suggested by our group in previous studies for the management of RAS.

Section snippets

Materials and Methods

The minocycline dose selected for the present study was equivalent to the accepted therapeutic dose of systemic minocycline (100 mg/day) used for controlling acne vulgaris.18 The study was designed as a randomized, double-blind, crossover study.

Twenty-nine consecutive patients seeking treatment for RAS at the Oral Medicine Clinic at the Sheba Medical Center were enrolled. Healthy patients over 18 years of age with over 4 RAS episodes per year and with no known allergy to minocycline were

Results

Twenty-nine patients with RAS who met the entry criteria were enrolled in the study. Eight patients did not experience any episode of RAS during the study period, and an additional 6 experienced only 1 episode within the time limit of the study. Only 1 patient dropped out of the study because of intolerance of the taste of the mouthwash. A total of 14 patients (8 males, 6 females) completed the 2 arms of the study. The mean age of the eligible patients was 32.5 years (range, 26-61 years). Only

Discussion

The efficacy and safety of aqueous solution of minocycline in the management of symptoms associated with RAS has been established.16, 17 In 2 previous randomized controlled studies, we demonstrated the superiority of minocycline mouthwash over placebo and over tetracycline-based mouthwash in terms of pain intensity and duration.16, 17 The present study demonstrated the superiority of a higher concentration of minocycline (0.5%) over the dosages that were evaluated in our previous studies

References (21)

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