Mucous membrane pemphigoid and pseudopemphigoid☆
Section snippets
Patient population
Since 1985, the Mucous Membrane Pemphigoid Clinic at The Johns Hopkins University School of Medicine has seen referrals typically for 1 of 2 reasons: (1) cicatrizing conjunctivitis in which ocular MMP is the suspected diagnosis; and (2) patients with diagnosed extraocular MMP, who are referred for evaluation of possible ocular involvement. Patients with MMP without ocular involvement typically were seen every 6 months for the occurrence of ocular disease. Those patients with ocular MMP were
Mucous membrane pemphigoid
Two hundred eighty consecutive patients were evaluated for possible ocular MMP between January 1, 1985, and December 31, 2001. There were 123 patients with MMP, 74 of whom had ocular involvement (with or without extraocular involvement), and 49 of whom had only extraocular disease at presentation. The demographic and clinical characteristics of patients with MMP are summarized in Table 1. Patients with MMP with ocular involvement at presentation were similar to those without ocular involvement
Discussion
MMP is an autoimmune disease that causes progressive scarring of the mucous membranes. Ocular MMP causes progressive conjunctival scarring that, if untreated, can lead to blindness.1, 7, 8 We reviewed our experience with MMP and pseudopemphigoid over 17 years. As in all retrospective studies, the data from this study must be interpreted with caution. A referral bias might exist, because our clinic is part of a tertiary care medical center, and it is possible that only the sickest and most
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Manuscript no. 220750.
Supported in part by grants K23 EY13707 (JET), R01 AI 48063 (GJA), and K24 EY00405 (DAJ) from the National Institutes of Health, Bethesda, Maryland. Dr Jabs is the recipient of a Research to Prevent Blindness Senior Investigator Award.