Original articleComparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography☆
Section snippets
Materials and methods
Eighty patients having 143 eyes with clinically significant DME as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) seen in a private retina practice were examined first by the physician and then by one of 2 certified ophthalmic photographers experienced in performing OCT. The clinical determination of DME was made by stereoscopic slit-lamp biomicroscopy using a noncontact 78-diopter (D) fundus lens. Although Goldmann contact lens biomicroscopy was the clinical examination
Results
The reference range for normal values of OCT scans is shown in Table 1. For comparison, the values for the patients with DME are listed in Table 2. For all 5 regions, the distributions of values in the patients with DME were shifted toward higher values (P values ranging from 0.0363 to 0.0005).
A sample 2×2 table comparing clinical and OCT assessments of retinal thickening is shown for the foveal zone (Table 3), as well as the method of calculation of the statistics quantitating agreement
Discussion
The reference range of values for the different zones obtained with OCT in this study are similar to those reported in other studies.2, 4 This suggests that OCT values between different settings are comparable, which is important information for planners of multicenter studies.
It is commonly recognized that the clinical assessment of DME is subjective and variable.2, 6 In the DRS and ETDRS, stereoscopic fundus photographs graded by technicians masked to clinical information were compared with
References (9)
- et al.
Topography of diabetic macular edema with optical coherence tomography
Ophthalmology
(1998) - et al.
Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease
Am J Ophthalmol
(2002) - et al.
Macular edema in Diabetic Retinopathy Study patients—Diabetic Retinopathy Study report number 12
Ophthalmology
(1987) - et al.
Detection of diabetic macular edemaophthalmoscopy versus photography - Early Treatment Diabetic Retinopathy Study report number 5
Ophthalmology
(1989)
Cited by (0)
- ☆
Manuscript no. 230054.
The authors have no proprietary interest in any of the materials used in this study.