Original articlePattern electroretinogram abnormality and glaucoma
Section snippets
Patients
Two hundred glaucoma suspect (GS) patients and 42 patients with early manifest glaucoma (EMG) participated in the study. The mean age of the entire group of patients was 57±13 years (median, 57 years). Black patients comprised 52 of the total 242-person population (21%; GS, n = 40; EMG, n = 12). Eligibility was determined through a detailed medical and ocular history and a comprehensive eye examination. Eye examination included best-corrected visual acuity (BCVA), refraction at distance and
Comparison between pattern electroretinogram of patients and control subjects
The PERG amplitude and phase decreased with aging in normal subjects (Fig 2).23 The thick lines represent the regressions of amplitude or phase as a function of age of the NC group, and the thin lines represent the corresponding 95% tolerance limits. Normal controls of black race were not significantly different from nonblacks with respect to PERG amplitude (P = 0.43, analysis of covariance adjusting for age) or PERG phase (P = 0.44). After adjusting for age, the mean PERG amplitude of black
Discussion
We designed this study to determine the prevalence of PERG abnormalities in patients with glaucomatous cupping and normal SAP and to assess the correlation of PERG abnormalities with risk factors for open-angle glaucoma. The goal was to evaluate the predictive potential of the PERG for the early diagnosis of glaucoma. The PERG results were abnormal in at least 1 of the outcome measures (amplitude, phase, interocular asymmetry in amplitude, and phase) in 52% of GS patients and in 69% of EMG
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Cited by (0)
Manuscript no. 240181.
Supported by The Glaucoma Foundation, New York, New York; Fight for Sight, New York, New York; Research to Prevent Blindness, Inc., New York, New York; and Rotary International, Evanston, Illinois.
Dr Porciatti has a patent pending application (no. PCT/US03/03155) on the technique for pattern electroretinogram recording.