Case reportCorrelation of Corneal Complications with Eyelid Cicatricial Pathologies in Patients with Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome
Section snippets
Patients and Methods
This study was approved by the Institutional Review Board of the Baptist Hospital of Miami and South Miami Hospital to retrospectively review the clinical data of patients with SJS or TENS seen at Ocular Surface Center, Miami, Florida, during the period from January 2002 to August 2004. We included patients with the diagnosis of SJS and TENS on the basis of the criteria previously summarized by Power et al.1 We also included 1 additional patient with an acute attack of SJS hospitalized in the
Lid Margin and Tarsal Ulceration Without Corneal Involvement and Successful Management by Amniotic Membrane Transplantation in Acute Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Syndrome
A 4-year-old boy, with a medical history of asthma and autism, had skin rashes of the face and neck develop the next day after taking ibuprofen to control fever. On the following day, both eyes were red, and blisters were noted in the mouth, resulting in eating difficulty. He was admitted to a pediatric intensive care unit with a presumptive diagnosis of SJS. The skin rashes affected 9% of the body in the ensuing 3 days of hospitalization. He kept both eyes closed and was treated with topical
Discussion
For SJS/TENS, severe inflammation and ulceration, if allowed to be recalcitrant and chronic, led to scarring (cicatrix). Depending on the site of involvement, such cicatrix may result in ATD (obliterating lacrimal excretory ducts), LTD (obliterating meibomian orifices), fornix shortening, symblepharon, ankyloblepharon, punctal stenosis, trichiasis and entropion. On the bulbar conjunctiva, it may cause squamous metaplasia, ranging from goblet cell loss to frank keratinization.8 On the limbus, it
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Infectious and Noninfectious Corneal Ulcers in Ocular Graft-Versus-Host Disease: Epidemiology, Clinical Characteristics, and Outcomes
2024, American Journal of OphthalmologyClinical Outcome of Amniotic Membrane Transplant in Ocular Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis at a Major Burn Unit
2023, American Journal of OphthalmologyVulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review
2021, International Journal of Women's DermatologyLid margin keratinization in Stevens-Johnson syndrome: Review of pathophysiology and histopathology
2021, Ocular SurfaceCitation Excerpt :The median time to the occurrence of this complication was also three months [6,8]. Although the exact etiopathogenesis of LMK has not been clearly elucidated, a number of potential mechanisms have been proposed [5,9]. Likewise, there are very limited studies on the histopathological findings of the lid margins in chronic SJS [10].
Lid-Related Keratopathy in Stevens-Johnson Syndrome: Natural Course and Impact of Therapeutic Interventions in Children and Adults
2020, American Journal of Ophthalmology
Manuscript no. 2004-43.
Supported in part by an unrestricted grant from Ocular Surface Research and Education Foundation, Miami, Florida.
Dr Tseng and his family are more than 5% shareholders of TissueTech, Inc., which owns United States patent nos. 6 152 142 and 6 326 019 on the method of preparation and clinical uses of human amniotic membrane, which is currently distributed by Bio-Tissue, Inc.