Original ArticleAlignment Artifacts in Optical Coherence Tomography Analyzed Images
Section snippets
Materials and Methods
The study was conducted in accordance with the ethical standards stated in the Declaration of Helsinki. Approval was obtained from the Clinical Research Ethics Committee of Hong Kong Hospital Authority Kowloon West Cluster to review the medical records of individuals who received OCT scans over the macular region during the period from July 2003 to June 2005 in the Department of Ophthalmology, Caritas Medical Centre, Hong Kong. All the OCT images were obtained using Stratus OCT with the use of
Comparisons between Manual and Automated Retinal Thickness Measurements in Normal Eyes
Manually measured foveal thicknesses from 30 normal eyes were compared with those generated automatically by OCT. After retinal thickness (single eye) analysis, 1 of the 6 linear macular images was selected randomly and exported to SigmaScan Pro. The foveal thickness at the 65th A-scan was measured (as described in “Materials and Methods”) and compared to the automated measurements at the corresponding position in each eye (Fig 3). The mean/median (range) foveal thicknesses were 149.7/147
Discussion
Reliable and accurate delineation of retinal boundaries for measurement of macular thickness in OCT macular scans is crucial in detecting macular abnormality, monitoring disease progression, and assessing therapeutic response. However, even with the latest commercially available OCT unit (Stratus OCT) and its attached image analysis software (version 4.0), retinal thickness miscalculation is still a commonly encountered problem. The major causes of the inaccuracies in retinal thickness
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Manuscript no. 2005-843.
The authors have no proprietary interest in the development or marketing of any product mentioned in the article, and the study received no financial support.