Original articleThe Influence of Tilt, Decentration, and Pupil Size on the Higher-Order Aberration Profile of Aspheric Intraocular Lenses
Section snippets
University of Auckland Model Eye
A physical model eye platform to analyze wavefront aberrations introduced by IOLs was designed and constructed for use with the Zywave (Bausch & Lomb, Rochester, NY) aberrometer as previously described.7 For the purposes of this study, specific modifications were incorporated to set the degree of IOL tilt, IOL decentration, and effective pupil size accurately.
The model consists of a Boston XO 45.0-diopter (D) corneal lens with an adjustable iris incorporating fixed pupil apertures at 5 mm, 3
Results
Preliminary experiments to validate the model showed consistent and reproducible results. Multivariate ANOVA analysis of third-, fourth-, and fifth-order Zernike modes demonstrated highly statistically significant results. All 4 variables had a statically significant effect on the HOA; however, the nature of this effect is complex and is highlighted best by the canonical discrimination analysis (CDA) plot (see Fig 1, available at http://aaojournal.org). Statistical significance for the MANOVA
Discussion
Aspheric IOLs are designed to improve visual performance; however, several recent studies have reported conflicting results when aspheric IOLs are compared with spherical IOLs.13, 14, 15 It has been suggested that decentration, tilt, pupil size, and IOL asphericity all could be factors in explaining these disparate results.13, 16 The physiologic variables that in vivo studies have to contend with make testing this hypothesis extremely challenging; therefore, the relative influence and
References (55)
- et al.
Optical performance of 3 intraocular lens designs in the presence of decentration
J Cataract Refract Surg
(2005) - et al.
Wavefront analysis in post-LASIK eyes and its correlation with visual symptoms, refraction, and topography
Ophthalmology
(2004) - et al.
Making sense out of wavefront sensing
Am J Ophthalmol
(2005) - et al.
Wavefront aberrometry: comparing and profiling higher-order aberrations produced by intraocular lenses in vitro using a physical model eye system and Hartman-Shack aberrometry
J Cataract Refract Surg
(2009) - et al.
Tilt and decentration of intraocular lenses in vivo from Purkinje and Scheimpflug imagingValidation study
J Cataract Refract Surg
(2007) - et al.
Intraindividual comparison of higher-order aberrations after implantation of aspherical and spherical intraocular lenses as a function of pupil diameter
J Cataract Refract Surg
(2006) - et al.
Prediction of flap response
J Cataract Refract Surg
(2005) - et al.
Effect of intraocular lens asphericity on quality of vision after cataract removal: an intraindividual comparison
Ophthalmology
(2009) - et al.
Analysis of the possible benefits of aspheric intraocular lenses: review of the literature
J Cataract Refract Surg
(2009) - et al.
Visual acuity and contrast sensitivity in eyes implanted with aspheric and spherical intraocular lenses
Ophthalmology
(2009)
Predictability of ocular spherical aberration after cataract surgery determined using preoperative corneal spherical aberration
J Cataract Refract Surg
Effect of decentration and tilt on the image quality of aspheric intraocular lens designs in a model eye
J Cataract Refract Surg
Intraocular lens centration and visual outcomes after bag-in-the-lens implantation
J Cataract Refract Surg
Tilt and decentration of three-piece foldable high-refractive silicone and hydrophobic acrylic intraocular lenses with 6-mm optics in an intraindividual comparison
Am J Ophthalmol
Decentration and tilt: silicone multifocal versus acrylic soft intraocular lenses
J Cataract Refract Surg
Tilt and decentration of spherical and aspheric intraocular lenses: effect on higher-order aberrations
J Cataract Refract Surg
Influence of intraocular lens optical design on high-order aberrations
J Cataract Refract Surg
Influence of intraocular lens tilt and decentration on wavefront aberrations
J Cataract Refract Surg
Decentration and tilt of a single-piece aspheric intraocular lens compared with the lens position in young phakic eyes
J Cataract Refract Surg
Contrast sensitivity function and ocular higher-order wavefront aberrations in normal human eyes
Ophthalmology
Effect of total higher-order aberrations on accommodation in pseudophakic eyes
J Cataract Refract Surg
Optical aberrations of the human anterior cornea
J Cataract Refract Surg
Wavefront aberrations, depth of focus, and contrast sensitivity with aspheric and spherical intraocular lenses: fellow-eye study
J Cataract Refract Surg
Interaction between aberrations to improve or reduce visual performance
J Cataract Refract Surg
Custom optimization of intraocular lens asphericity
J Cataract Refract Surg
Spherical aberration and depth of focus
Ophthalmology
Spherical aberration and depth of focus in eyes implanted with aspheric and spherical intraocular lenses: a prospective randomized study
Ophthalmology
Cited by (84)
Advances in the Management of Dislocated Intraocular Lenses
2024, Advances in Ophthalmology and OptometryEvaluation and Management of Postoperative Complications Following Cataract Extraction and Intraocular Lens Placement
2024, Advances in Ophthalmology and OptometryIntraocular lens tilt due to optic-haptic junction distortion following intrascleral haptic fixation with the Yamane technique
2023, American Journal of Ophthalmology Case ReportsRisk Factors Associated With Intraocular Lens Decentration After Cataract Surgery
2022, American Journal of OphthalmologyClinically Significant Intraocular Lens Decentration and Tilt in Highly Myopic Eyes: A Swept-Source Optical Coherence Tomography Study
2022, American Journal of Ophthalmology
Manuscript no. 2010-909.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.