Original articleDiagnostic Capability of Lamina Cribrosa Thickness by Enhanced Depth Imaging and Factors Affecting Thickness in Patients with Glaucoma
Section snippets
Materials and Methods
The study used a cross-sectional, case-control design and enrolled 165 Korean adults with glaucoma and 75 normal controls (healthy volunteers). Participants were recruited from Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, between June 2010 and February 2012. In cases with both eyes eligible for the study, 1 eye was randomly chosen for inclusion.
The study was performed with the informed consent of the participants and followed all guidelines for experimental
Results
Spectralis peripapillary RNFL thickness and EDI OCT images of the ONH were observed in 165 patients with glaucoma and 75 normal controls. Among the patients with glaucoma, 21 (12.7%) had unclear lamina structures or posterior borders and thus were excluded. Ten normal controls (13.3%) were excluded for the same reason. The remaining 144 patients (68 with POAG and 76 with NTG) and 65 normal controls were considered for analysis.
Discussion
By providing objective, quantitative, and reproducible measurements of RNFL thickness, OCT provides supplemental information that may help to differentiate glaucomatous eyes from normal eyes.18, 19 With the advent of SD-OCT, unprecedented high-resolution, high-speed RNFL imaging has been possible.20, 21 The Spectralis OCT system is one of many commercially available SD-OCT instruments. With its faster scan speeds and eye-tracking system, the Spectralis OCT system may reduce the variability of
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2024, American Journal of OphthalmologyRole of the lamina cribrosa in the pathogenesis of glaucoma. A review of the literature
2022, Journal Francais d'OphtalmologieElucidation of the role of the lamina cribrosa in glaucoma using optical coherence tomography
2022, Survey of OphthalmologyCitation Excerpt :The visualization of the laminar posterior surface is more difficult in normal and mild glaucomatous eyes because of the shading caused by the neural tissue and vessels.26,57,96,99 Various imaging devices have been used to evaluate the LC in vivo, including confocal laser scanning21,69,71,76,138, laser scanning ophthalmoscopy associated with adaptive optics,3,126 and OCT.2,22,34,41,51,59–63,70,80,83,85,88,92,94,95,108,128,129,141 OCT is the technology that has been most often used in LC studies, and one of the main reasons is that there have been rapid technological improvements, both in the speed of imaging and the quality of the images obtained. Classically, both the time domain OCT (TD-OCT) and spectral domain OCT (SD-OCT) using the principle of low coherence interferometry provide two-dimensional and cross-sectional images, resulting from the optical dispersion produced by microstructures of ocular tissues.33
Laminar and Prelaminar Tissue Characteristics of Glaucomatous Eyes Using Enhanced Depth Imaging OCT
2021, Ophthalmology GlaucomaComparison of the lamina cribrosa parameters in eyes with exfoliation syndrome, exfoliation glaucoma and healthy subjects
2020, Photodiagnosis and Photodynamic TherapyEvaluation of lamina cribrosa in angioid streaks using spectral-domain optical coherence tomography enhanced depth imaging
2019, Journal Francais d'OphtalmologieCitation Excerpt :Therefore, Park et. al suggest that a thinner LC in normal-tension glaucoma would make the ONH vulnerable to glaucomatous damage at relatively lower intraocular pressure levels than in high-tension glaucoma eyes [18]. Interestingly, patients with pseudoexfoliation glaucoma demonstrate structural alterations in the LC resulting from dysregulated elastosis rather than elevated intraocular pressure [19].
Manuscript no. 2012-543.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.