Original articleDietary Patterns and Their Associations with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study
Section snippets
Study Population
The MCCS recruited 41 514 participants (24 469 women) aged 40 to 69 years at baseline (1990–1994) to examine links between diet and chronic diseases.25, 26 To broaden the range of dietary intakes, participants born in Greece and Italy were deliberately oversampled to comprise one quarter of the cohort, whereas participants born in Australia, New Zealand, and United Kingdom made up the remainder of the cohort.25
Of the total sample, 27 883 (67%) attended a follow-up examination between 2003 and
Results
Of the 22 405 participants who had retinal photographs assessed, 21 132 (94%) had retinal photographs gradable for AMD. After excluding 1364 participants at the extreme 1% of energy intake at baseline (n = 311) and participants with a history of heart attack/angina/stroke (n = 688) or diabetes at baseline (n = 365) (with the potential for dietary modification), we included the remaining 19 768 participants in the analysis.
Of the 19 768 participants, 2508 (12.7%) had early stages of AMD and 108
Discussion
The MCCS presents a unique opportunity to study links between diets and those with AMD, because it is the largest single cohort study with comprehensive data on both diet and AMD status. With the use of PCA, we identified 6 dietary factors (patterns) at baseline. Of note, fruit and vegetables ended up in different factors in our data. We observed that participants born in Australia, New Zealand, and the United Kingdom scored higher on the “vegetable” factor, whereas those born in Italy and
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Cited by (55)
Intake of Vegetables, Fruit, and Fish is Beneficial for Age-Related Macular Degeneration
2019, American Journal of OphthalmologyCitation Excerpt :Our findings are consistent with recent studies on dietary patterns and AMD. The Melbourne collaborative cohort study showed that higher intake of grains and fish considerably reduced the risk of late AMD.14 Intake of vegetables and fruit alone was not associated with late AMD; unfortunately, the combined intake of these foods was not studied.
Adherence to a mediterranean diet and its association with age-related macular degeneration. The Coimbra Eye Study–Report 4
2018, NutritionCitation Excerpt :When looking at each food group individually, we observed that an increased intake of vegetables, fruit, and nuts was associated with no AMD. This result is in agreement with previous publications [36] and biologically plausible [37,38] because these foods are high in antioxidants. Therefore, one might consider it likely that vegetables, fruit, and nuts drive the results that are observed in our study and thus, the potential protective effect of the Mediterranean diet in AMD.
A NARRATIVE REVIEW on DIETARY COMPONENTS & PATTERNS and AGE-RELATED MACULAR DEGENERATION
2024, Nutrition Research ReviewsAge-related Macular Degeneration Risks linked with Indian Dietary Fat Consumption Patterns
2023, Current Research in Nutrition and Food Science
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Funding: Victoria Health, The Cancer Council Victoria, and National Health & Medical Research Council of Australia (NHMRC) (*Program Grant 209057, Capacity Building Grant 251533, and Enabling Grant 396414) funded the MCCS study. Ophthalmic component was funded by the Ophthalmic Research Institute of Australia and American Health Assistance Foundation. People support was provided through the NHMRC Practitioner Fellowships (R.H.G.), NHMRC Senior Research Fellowships (P.N.B. and J.L.H.), and Macular Degeneration Foundation Blackmores Dr. Paul Beaumont Research Fellowship (L.D.R.). The Centre for Eye Research Australia is a recipient of the NHMRC Centre for Clinical Research Excellence Grant 529923 and Operational Infrastructure Support from the Victorian Government.
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Drs. Islam and Chong contributed equally to this article as first authors.