Original articleMicrostructure of β-Zone Parapapillary Atrophy and Rate of Retinal Nerve Fiber Layer Thinning in Primary Open-Angle Glaucoma
Section snippets
Methods
The participants in this study comprised patients from the Investigating Glaucoma Progression Study (IGPS), which is an ongoing prospective study on patients with glaucoma at the Seoul National University Bundang Hospital Glaucoma Clinic. They were consecutive patients who met the eligibility criteria and provided written informed consent to participate. This study was approved by the Seoul National University Bundang Hospital Institutional Review Board and followed the tenets of the
Baseline Characteristics
The study included 195 eyes of 195 patients with POAG who met the eligibility criteria, of whom 154 eyes had temporal β-zone PPA and were further classified into groups A (having PPA+BM only; n=64), B (having both PPA+BM and PPA–BM; n=58), and C (having PPA–BM only; n=32). The remaining 41 eyes did not have β-zone PPA and were categorized as group D (lacking β-zone PPA).
The interobserver agreement of determining the presence or absence of β-zone PPA on infrared fundus imaging was excellent
Discussion
Differences in the clinical characteristics between PPA types have been categorized according to the extent of the existing BM in the β-zone PPA area, and diverse mechanisms underlying the pathogenesis of PPA among POAG patients have been suggested. This study identified differences in the rate of RNFL thinning according to PPA type.
The findings of this study suggest that the risk of progressive RNFL thinning is greater in eyes having PPA with PPA+BM only (group A) than in eyes with other types
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Funding: Supported by National Research Foundation of Korea Grant funded by Korean Government (800-20130242). The funding organization had no role in the design or conduct of this research.