Original articleEfficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs
Section snippets
Methods
In the current study, 70 000 fundus photographs were downloaded by random sampling from the online dataset LabelMe (Healgoo Ltd. LabelMe dataset; 2016. http://www.labelme.org. Accessed February 16, 2016.), which contains more than 200 000 color fundus photographs collected from various clinical settings in China. Subsequently, 48 116 images with a visible optic disc were selected for the labelling of GON.
Approval from the institutional review board of Zhongshan Ophthalmic Center was obtained
Results
A total of 48 116 fundus photographs were graded for glaucoma by program-trained ophthalmologists, with each fundus photograph graded between 3 and 9 times. The median quantity of images per ophthalmologist graded was 3337 (range, 407–34 621). Twelve graders graded more than 3000 images. The median accuracy of the ophthalmologist graders (n = 15) for referable glaucoma was 82.1% (range, 76.0%–86.5%). A total of 5340 images were graded as poor quality and 3031 were labeled as poor location, and
Discussion
In this study, the efficacy of the deep learning method in identifying referable GON based on 48 116 fundus photographs was investigated. This deep learning algorithm showed a robust performance (AUC, 0.986; sensitivity, 95.6%; and specificity, 92.0%) for the detection of referable GON. Recently, several reports of automated methods for the evaluation of glaucoma have been published.30, 31, 32, 33, 34 Singh et al30 developed a technique using wavelet feature extraction techniques from segmented
Acknowledgments
The authors thank Zehong Zhou, International Department, Affiliated High School of South China Normal University, for his contributions to the data cleaning, integration, and convolutional neural network construction.
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Cited by (0)
Financial Disclosure(s): The author(s) have made the following disclosure(s): W.M.: Patent – Using deep learning models to process color fundus images
M.H.: Patent – Using deep learning models to process color fundus images
Supported in part by the Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China (grant no.: 81420108008); the Science and Technology Planning Project of Guangdong Province (grant no.: 2013B20400003); the University of Melbourne at Research Accelerator Program of Australia (M.H.); the CERA Foundation of Australia (M.H.); Victorian State Government of Australia (Operational Infrastructure Support to the Centre for Eye Research Australia); and Research to Prevent Blindness, Inc., New York (to Stanford University Eye Department). The sponsors or funding organizations had no role in the design or conduct of this research.
HUMAN SUBJECTS: Human subjects were included in this study. The institutional review board of Zhongshan Ophthalmic Center approved the study and determined that informed consent was not required because of retrospective nature and fully anonymized usage of images in this study. The study was performed in accordance with the tenets of the Declaration of Helsinki.
No animal subjects were used in this study.
Author Contributions:
Conception and design: Li, Meng, M.He
Analysis and interpretation: Li, Keel, Chang
Data collection: Li, Y.He, Keel, Meng
Obtained funding: None
Overall responsibility: Li, Y.He, Keel, Chang, M.He
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These authors contributed equally as first authors.