Elsevier

Physiology & Behavior

Volume 173, 1 May 2017, Pages 298-304
Physiology & Behavior

Time-restricted feeding on weekdays restricts weight gain: A study using rat models of high-fat diet-induced obesity

https://doi.org/10.1016/j.physbeh.2017.02.032Get rights and content
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Highlights

  • A time-restricted feeding regimen (TRF) was tested, i.e., no food consumption during inactive phase daily for 5 weekdays, but not for weekend.

  • This special TRF restricted weight gain in juvenile rats.

  • Total calorie intake per week was not reduced by this special TRF regimen.

Abstract

A recent study reported that a special weekly scheduled time-restricted feeding regimen (TRF), i.e., no food consumption for 15 h during the light (inactive) phase per day for 5 weekdays, attenuated the outcome of diverse nutritional challenges in response to high-fat diet in mice. In the present study, we wanted to further test whether this TRF could restrict body weight gain in both juvenile and adult animals when fed a high-fat diet. Fifty male Sprague-Dawley rats at ages from 5 to 27 weeks were used. First, we found that freely fed rats with 60% fat diet gained weight significantly, which was associated with more calorie intake (particularly during light phase) than those fed standard food (7% fat). Secondly, we found that TRF restricted high-fat diet-induced weight gain in both groups of juvenile rats (5 and 13 weeks of age) compared to freely fed rats with high-fat diet, despite the same levels of 24 h-calorie intake during either weekdays or the weekend. Thirdly, we found that TRF did not restrict high-fat diet-induce weight gain in adult rats (27 weeks of age). Thus, we suggest that this special TRF regimen could be further tested in humans (particularly young adults) for the purpose of obesity prevention.

Keywords

Body weight
Circadian rhythm
Food intake
Feeding behavior
Obesity

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