Regional brain volumes and symptom severity in body dysmorphic disorder
Introduction
Body dysmorphic disorder (BDD) is a severe psychiatric condition in which patients are preoccupied with perceived defects in their appearance. This causes them to believe they are disfigured and ugly, and causes significant suffering and functional impairment. Most patients with BDD have poor insight, and 36–38% are classified as delusional (Eisen et al., 2004, Phillips et al., 2006). BDD affects 1–2% of the population (Faravelli et al., 1997, Otto et al., 2001, Rief et al., 2006), and is associated with high rates of psychiatric hospitalization (48%) (Phillips and Diaz, 1997) and suicide attempts (22–27.5%) (Veale et al., 1996, Phillips and Diaz, 1997, Phillips et al., 2005).
Despite the prevalence and severity of this disorder, very little is known of the pathophysiology or neurobiology of BDD. Only one previous morphometric magnetic resonance imaging (MRI) study in BDD has been published. In this study eight females, some of whom were medicated, demonstrated greater total white matter compared with controls and a leftward shift in caudate asymmetry (Rauch et al., 2003a), which the authors interpreted as suggesting similar striatal pathophysiology to that in obsessive-compulsive disorder (OCD) (Saxena et al., 2001). A small functional imaging study of six BDD patients, using single photon emission computed tomography (SPECT), showed variable, discrepant findings including relative perfusion deficits in bilateral anterior-medial temporal and occipital regions and asymmetric perfusion in parietal lobes (Carey et al., 2004). This study, however, had no control or comparison group. We recently performed a functional magnetic resonance imaging (fMRI) study in BDD that examined visual processing of faces (Feusner et al., 2007). Individuals with BDD as compared with healthy controls demonstrated abnormal activation patterns that included greater left hemisphere activity in regions including the inferior frontal gyrus, as well as abnormal amygdala activation (R > L). No other neuroimaging studies of BDD have been published.
Given these previous findings and the paucity of data on the neurobiology of BDD, the objective of this study was to further investigate regional brain volumes in BDD as compared with healthy controls. Based on our fMRI findings (Feusner et al., 2007), we selected the inferior frontal gyrus (IFG) and the amygdala as regions of interest. Following up the previous morphometric MRI study's findings (Rauch et al., 2003a), we also examined total grey matter (GM), white matter (WM), and the caudate as a region of interest, and calculated laterality quotients. We also tested whether brain volumes in the regions of interest were correlated with symptom severity. In addition, we performed voxel-based morphometry for regional whole-brain analysis to detect any other brain volume differences. We hypothesized that in the BDD group there would be abnormal caudate asymmetry and greater total WM. Based on findings from our previous fMRI study in the same cohort of BDD patients, we also hypothesized that they would demonstrate greater volumes of the amygdalae and left IFG, given the previously found hyperactivity in these regions. In addition, we hypothesized that symptom severity would positively correlate with size of the left IFG and bilateral amygdalae. A better understanding of patterns of brain morphometry in BDD could assist in understanding the pathophysiology underlying the clinical symptoms, as well as how it relates to other disorders with similar features.
Section snippets
Subjects
The UCLA Institutional Review Board approved the protocol for the study. We obtained informed consent from 12 subjects with BDD and 12 healthy controls, ages 18 to 54 (mean 28.7 ± 10), recruited from the community. The BDD group and controls were matched by gender, age, and level of education, and all were right-handed, as determined by the Edinburgh Handedness Inventory (Oldfield, 1971). All BDD subjects met DSM-IV criteria for body dysmorphic disorder, as determined by the first author (Dr.
Characteristics of the subject group
Table 1 summarizes the demographic and psychometric data for both groups. The average BDD-YBOCS score was 28.7 ± 7.0. One BDD subject had comorbid major depressive disorder, one had dysthymic disorder, two had generalized anxiety disorder, and two had both major depressive disorder and generalized anxiety disorder. The BDD symptoms were the primary concern in every subject. Typical of this population, all 12 subjects had preoccupations with perceived facial defects.
Volumetric and region of interest analyses
There were no significant
Discussion
The principal finding in this study is that BDD symptom severity correlates significantly with the size of the left IFG and the right amygdala. These were the regions of interest selected based on abnormal hyperactivity from the previous fMRI study in the same cohort (Feusner et al., 2007). As we did not detect significant volumetric differences from the voxel-based morphometry or segmented analyses, the nature of the morphometric findings appears not to be in gross morphometry at the group
Acknowledgements
Funding for this study was provided by the Saban Family Foundation and an NIMH grant K23MH079212-02 (Dr. Feusner).
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