Elsevier

Redox Biology

Volume 4, April 2015, Pages 6-13
Redox Biology

Graphical Review
Mitochondrial dynamics and mitochondrial quality control

https://doi.org/10.1016/j.redox.2014.11.006Get rights and content
Under a Creative Commons license
open access

Highlights

  • Mitochondrial dynamics including mitochondrial fission/fusion and mitochondrial movement regulate mitochondrial homeostasis and quality.

  • Damaged mitochondria are removed via multiple mechanisms including mitophagy, mitochondrial derived vesicles and mitochondrial spheroids.

  • Mitophagy can occur in a Parkin-dependent or independent manner.

  • Parkin also regulates the formation of mitochondrial derived vesicles and mitochondrial spheroids.

Abstract

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and fusion as well as movement through the cytoskeleton. In this review, we discuss the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy. We also discuss multiple pathways leading to the quality control of mitochondria in addition to the traditional mitophagy pathway under different conditions.

Abbreviations

APAP
acetaminophen
Bag4
Bcl2-associated athanogene 4
Bcl2L1
Bcl-2 like 1
BNIP3
Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3
CCCP
m-chloro phenyl hydrazine
Clec16a
C-type lectin domain family 16, member A
Drp1
dynamin-related protein 1
Fis1
mitochondrial fission 1
FUNDC1
Fun14 domain containing 1
Hif-1
hypoxia-inducing factor 1
HSPA1L
heat shock 70 kDa protein 1-like
LC3
microtubule-associated protein 1 light-chain 3
LIR
LC3-interacting region
MEFs
mouse embryonic fibroblasts
Mff
mitochondria fission factor
Mfn1
mitofusin 1
Mfn2
mitofusin 2
MDV
mitochondria-derived vesicles
MID49
mitochondrial dynamics protein of 49 kDa
Miro
mitochondrial Rho GTPase
MUL1
mitochondrial ubiquitin ligase 1
Nrdp1
neuregulin receptor degradation protein 1
OPA1
optic atrophy 1
PARL
presenilin-associatedrhomboid-like
PGAM5
phosphoglycerate mutase family member 5
PINK1
PTEN-induced putative kinase 1
ROS
reactive oxygen species
Smurf1
Smad-specific E3 ubiquitin protein ligase 1
SQSTM1
sequestosome 1
SNPH
syntaphilin
TOMM7
translocase of outer mitochondrial membrane 7
TOMM20
translocase of outer mitochondrial membrane 20
UBA
ubiquitin-associated
Usp30
ubiquitin-specific peptidase 30
VDAC
voltage-dependent anion channel

Keywords

Autophagy
Mitophagy
Parkin
Mitochondrial spheroids

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