Elsevier

Respiratory Medicine

Volume 118, September 2016, Pages 65-75
Respiratory Medicine

Review article
Inhalation device requirements for patients' inhalation maneuvers

https://doi.org/10.1016/j.rmed.2016.07.013Get rights and content
Under a Creative Commons license
open access

Highlights

  • Limit values of inspiratory flow requirements for inhalation devices are presented.

  • Information on flow acceleration, inspiratory time, inspiratory volume is given.

  • New measuring algorithm enables evaluation of individual inhalation maneuvers.

Abstract

Background

Inhaled drugs are the mainstay of treatment for lung diseases such as asthma and chronic obstructive pulmonary disease. However, failure to use inhalation devices correctly can lead to a poorly controlled status. A vast number of inhalation devices exist and each device has specific requirements to achieve optimum inhalation of the drug. Currently, there is no overview of inhalation requirements considering all devices. This article presents a review of the literature on different inhalation device requirements and incorporates the data into a new inhalation flow algorithm.

Methods

Data from literature on commercially available inhalation devices were evaluated and parameters, such as inhalation flow rate, flow acceleration, inhalation volume, and inspiration time assessed for the required inhalation maneuver specific to the device. All agreed upon data points were used to develop an inhalation flow algorithm.

Results

The literature analysis revealed availability of robust data for the required inhalation flow characteristics for most devices and thus for the development of an algorithm. For those devices for which these parameters are not published, the minimum required flow criteria were defined based on published data regarding individual aspects of aerosol quality.

Conclusions

This review provides an overview of inhalation devices available on the market regarding requirements for an acceptable inhalation maneuver and shows which goals should be achieved in terms of inhalation flows. The presented algorithm can be used to develop a new computer based measurement system which could help to test and train patients' individual inhalation maneuvers with their inhalation devices.

Keywords

Inhalation device
Inspiratory flow rate
Inhalation maneuver
Inhalation maneuver quality
Drug delivery

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