REGULAR ARTICLEIFN-γ-induced apoptosis of human embryonic stem cell derived oligodendrocyte progenitor cells is restricted by CXCR2 signaling
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Highlights
► Cultured hOPCs were susceptible to IFN-γ-induced apoptosis. ► Treatment of hOPCs with IFN-γ induced expression of CXCL10 that also contributed to apoptosis. ► Signaling through the chemokine receptor CXCR2 protected hOPCs from either IFN-γ or CXCL10-mediated apoptosis. ► ES-derived OPCs are susceptible to inflammatory cytokine/chemokine-mediated apoptosis yet protection is evoked if ligands for CXCR2 are present.
Abbreviations
OPC
oligodendrocyte progenitor cell
hESC
human embryonic stem cell
CXCL10
CXC chemokine ligand 10
MS
multiple sclerosis
SCI
spinal cord injury
JHMV
mouse hepatitis virus
RA
retinoic acid
GRM
glial restrictive media
EGF
epidermal growth factor
NGS
normal goat serum
GalC
galactocerebroside
MTT
3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide
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