Inherited Renal Tubulopathies Associated With Metabolic Alkalosis: Effects on Blood Pressure
Section snippets
Inherited Tubulopathies With Metabolic Alkalosis
Patients with inherited tubulopathies leading to metabolic alkalosis are clinically characterized by hypokalemia and increased K+ in urine (>20 mEq/L).13 Other nonrenal disorders impairing the tubular NaCl transport and diseases with body volume imbalance could mimic tubulopathies and therefore need to be excluded before establishing a definitive diagnosis. Differential diagnosis should include causes of hypokalemia and volume contraction such as K+-deficient intake, or increased K+ wasting of
Inherited Tubulopathies With Hypokalemia and Normotension: Bartter’s and Bartter’s-Like Syndromes
Bartter’s syndrome and Bartter’s-like syndromes produce renal salt wasting caused by the loss of function of specific tubular transport mechanisms involved in distal NaCl reabsorption (Fig 1).16
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