American Association of Endocrine SurgeonsPatterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression
Section snippets
Specimens
A total of 41 WDPTC, 43 PDTC, and 22 ATC specimens were selected from the Memorial Sloan-Kettering Cancer Center (MSKCC) Pathology Database. The specimens were reviewed by our endocrine pathologist (R.A.G.) to ensure proper histologic diagnosis. PTC included papillary thyroid cancers displaying “ground glass” nuclei (“Orphan Annie eye” nuclei) without a significant degree of mitotic activity, necrosis, or nuclear pleomorphism. Only classical and follicular variants of papillary carcinoma were
Ki-67 expression
Only 2 (5.4%) of 37 WDPTC overexpressed Ki-67, whereas 21 (48.8%) of 43 PDTC and 18 (81.8%) of 22 ATC were Ki-67 positive. All aspects of this increase in Ki-67 were statistically significant, WDPTC versus PDTC or ATC (P < .0001) and PDTC versus ATC (P = .015) (Fig 1).
p53 expression
None of the 37 WDPTC expressed p53, whereas 5 (11.6%) of 43 PDTC and 7 (31.8%) of 22 ATC were p53 positive. In regard to p53 overexpression, there was a statistically borderline significant correlation between WDPTC versus PDTC (P
Discussion
This study was undertaken to further our understanding of thyroid carcinoma progression at the molecular level with the hope of identifying useful diagnostic and therapeutic markers. For this purpose, we studied a cohort of pathologically well-characterized thyroid carcinomas of follicular cell origin encountered at a single institution. Because the histopathologic definition of certain thyroid tumors (such as PDTC) can vary, all cases included in this study were subjected to a standardized
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