Original CommunicationInterferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer
Section snippets
Patients and methods
This study was approved by the Ethics Committee of Akita University School of Medicine. The study participants were 110 Japanese patients treated surgically without neoadjuvant therapy for thoracic esophageal cancer at Akita University Hospital between April 2003 and April 2008. Of the 110 patients, 33 received surgery consecutively between April 2007 and April 2008. The remaining 77 patients were selected at random for participation in the study from among those patients undergoing
Statistical analysis
Values are expressed as means ± standard deviations. Differences in genotype frequency were analyzed using the Pearson χ2 or Fisher exact tests of independence; the frequencies were evaluated to determine whether they were consistent with the expected Hardy-Weinberg proportions. Differences between groups were analyzed using the Student t test, Pearson χ2, or Fisher exact test. Relationships to infectious complications after esophagectomy were tested using univariate logistic regression
Results
The patient population included 96 males and 14 females with an average age of 64 ± 8 years (range, 38–82). Of the 110 lesions, 7 (6%) were located in the upper thoracic esophagus, 57 (52%) in the mid-thoracic segment, and 46 (42%) in the lower thoracic segment. For esophageal reconstruction, the gastric tube was used in 103 (94%) patients, pedicled colon in 6 patients, and pedicled jejunum in 1 patient. As a route of reconstruction, the posterior mediastinal route was used in 104 (95%)
Discussion
This study revealed that there is a significant correlation between the INF-γ 874A>T genetic polymorphism and infectious complications following esophagectomy in a cohort of patients with esophageal cancer. Adjusting for covariates, patients carrying the INF-γ 874A/T genotype appear to be more than 3.4 times as likely to develop a postoperative infection following esophagectomy than patients carrying the INF-γ 874A/A genotype. In contrast, there was no correlation between the other cytokine
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