Society of University SurgeonsThe influence of donor age on liver regeneration and hepatic progenitor cell populations
Section snippets
Grouping and donor characteristics
LDLT donors from January 2005 to December 2009 were retrospectively reviewed and divided into 2 groups (Group O, donor age ≥ 50 years, n = 6 and Group Y, donor age ≤ 30 years, n = 9) (Table 1). In Group Y, all the donors were men (age: 21–29 years), whereas in Group O, there were 3 men and 3 women donors (age: 50–65 years). The graft types comprised 5 right lobes without the middle hepatic vein (MHV) and 10 left lobes with the MHV. The postoperative courses of all donors were uneventful.
Evaluation of liver regeneration
Remnant
Donor liver regeneration rate
Interestingly, the RR value on POD 7 was significantly higher in Group Y than in Group O (Group Y, 1.22, vs Group O, 1.06; P = .027) (Fig 1, A). The RR value of the right lobe donor group was higher than that of the left lobe donor group (Fig 1, B). A subgroup analysis demonstrated that the RR value of the both right and left lobe donor group was higher in Group Y compared to Group O on POD 7. No significant difference was noted in the RR value between Group O and Y on POD 30 in either the
Discussion
Donor hepatectomy is the only procedure that injures the normal liver; therefore, investigation of liver regeneration after donor hepatectomy is the best and most accurate approach to elucidate the timeline of liver regeneration in a clinical setting.
Previous studies have shown that the mean liver volume 6 months after donor hepatectomy was 90.7% of the initial liver volume,17 and that the livers of the right lobe donor group regenerated faster than those of the left lobe donor group.18 Our
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Supported by a Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (#21591763, S.K.).