Original CommunicationKi-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms
Section snippets
Methods
The medical records of patients with PNENs treated surgically at Barnes-Jewish Hospital/Washington University School of Medicine from 1994 to 2009 were retrospectively reviewed. Any patient with insufficient clinical follow-up or whose pathologic specimen did not allow for Ki-67 staining (too little tissue remaining) was excluded. Demographic data were collected, including gender, ethnicity, age at operation, location of tumor (proximal versus distal); type of operation (enucleation, Whipple
Results
From April 1, 1994, to April 1, 2009, 156 patients were treated surgically for PNENs. Complete medical records and tissue samples were available in 140. Sixteen (11.4%) patients were found to have stage IV disease at the time of operation and were excluded from primary analysis. Patient demographics can be found in Table I. Twenty-nine (20.7%) patients experienced recurrence of disease. Nineteen (13.6%) patients had known multiple endocrine neoplasia (MEN) type I syndrome and 22 (15.7%)
Discussion
The incidence of PNENs is increasing, probably in large part because of increased recognition of the disease. Many small tumors are identified incidentally because of increased utilization of cross-sectional imaging. The likelihood of finding small, nonfunctional PNENs is likely rising at a faster rate than that of functional PNENs. It may be that many of these small tumors in elderly individuals might never become symptomatic. Identifying risk factors and creating a prognostic staging system
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Cited by (0)
Funded by the Washington University Surgical Oncology Training Grant (NIH-5T32CA00962122), the Doug Phillips Fund for Pancreatic Cancer Research and the Siteman Cancer Center Support Grant (NIH-2P30CA09184209).