Evaluation of the fate and pathological response in the lung and pleura of brake dust alone and in combination with added chrysotile compared to crocidolite asbestos following short-term inhalation exposure
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Abbreviations
Crl: Wi(Han)
Wistar rats, Specific Pathogen Free from Charles River Deutschland
SEM
scanning electron microscope
WHO
World Health Organization
MMMF
man made mineral fibers
VDI
Verein Deutscher Ingenieure (English, Association of German Engineers)
GMD
Geometric mean diameter
GML
Geometric mean length
GSD
Geometric standard deviation
MMAD
Mass median aerodynamic diameter
%CT/FOV
percentage of the elastin and collagen per area of lung tissue
CM
Confocal microscopy
TGF-ß
Transforming growth factor (TGF)-β
bFGF
Basic fibroblast growth factor
PDGF
Platelet-derived growth factor
CTGF
connective tissue growth factor
Keywords
Brake dust
Chrysotile
Crocdiolite asbestos
Fiber inhalation toxicology
Lung
Pleura
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Copyright © 2014 The Authors. Published by Elsevier Inc.