Organ donationClinical considerationDonors With Positive Blood Culture: Could They Transmit Infections to the Recipients?
Section snippets
Materials and methods
This study reflects the results of a retrospective analysis from January 1996 to June 2004. Serial blood samples, urine samples, and other samples from all donors were routinely obtained for culture before organ procurement. We studied 268 donors and classified them according to blood culture results: group 1, donors with negative blood culture (n = 216) versus group 2, donors with positive blood culture (n = 52).
All donors with positive blood cultures were included in this analysis, regardless
Results
Fifty-two of 268 donors showed bacteremia and 216 did not. Group 1 donors did not differ from group 2 with regard to age, cause of death, temperature, leukocytes, and type of harvested organs. Group 2 donors had stayed significantly more days in the intensive care unit (ICU): group 1 (3.14 ± 3) versus group 2 (4.39 ± 3.38 days; P = .038).
One hundred eleven group 1 donors (51.3%) and 27 group 2 donors (51.9%) had received antibiotic treatment. Amoxyclavulanic acid was administered to 80% group 1
Discussion
Recently, some authors have suggested that potential individuals with positive blood cultures can be considered to be viable donors and that their organs can be transplanted safely.1, 2, 3, 4 Donors with sepsis and multiorganic failure at the moment of organ procurement or donors infected with multiresistant organisms would be the exceptions.
In our study, upon careful review, we could find no case where a bacteria isolated from the blood of a donor matched a positive culture in the
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Cited by (39)
Liver transplantation from a donor with multidrug-resistant Acinetobacter baumannii infection. Is it a risk?
2023, Revista de Gastroenterologia de MexicoSafe Use of Infected Donor Organs in Kidney Transplantation
2020, Transplantation ProceedingsCitation Excerpt :The encountered microorganisms are variable between different locations and even across time in the same setting; therefore, knowing the trends in local microbiota or having data on isolated microorganisms from the donor is key. Several series and case reports found in the literature indicate that, provided adequate antibiotics are administered, there are low rates of infectious and noninfectious complications [8–17]. In our cohort, similar results were achieved with no increase in duration of hospital stay, rates of delayed graft function, rejection episodes, or thrombosis nor greater surgical complications as a disruption of the arterial anastomosis or urinary leak.
EASL Clinical Practice Guidelines: Liver transplantation
2016, Journal of HepatologyDiagnostic and management strategies for donor-derived infections
2013, Infectious Disease Clinics of North AmericaCitation Excerpt :Historical cases have alerted clinicians to the potentially catastrophic consequences of bacterial transmission from donor to recipient, such as graft infections, arterial anastomotic disruption, poor initial graft function, and sepsis.25 Recent data have not demonstrated these outcomes, however, and a review of 3 recent retrospective analyses showed zero transmission rates in such recipients.25–27 It is likely that the modern practice of routine administration of broad-spectrum antimicrobials for perioperative prophylaxis has decreased the rate of bacterial transmission from organ donors, accounting for the lower reported incidence and clinical sequelae of transmission.
Evaluation of bacterial infections in organ transplantation
2012, ClinicsCitation Excerpt :Alguns estudos mostram que as bacteremias no doador, quando identificadas e tratadas, tanto no receptor quanto no doador, não representam risco de infecção para o receptor. Quatro estudos avaliam a evolução de transplantados que receberam órgãos de doadores com bacteremia documentada (7–10). Lumbreras et al. identificaram 5% de bacteremias em doadores de fígado e coração (10).
Infection in renal transplant recipients
2010, Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rector's The Kidney - Expert Consult: Online and Print