Liver transplantationOutcomeOutcome of Patients With Recurrent Hepatocellular Carcinoma in Liver Transplantation
Section snippets
Patients and methods
Among 156 liver transplant patients for HCC from June 1996 to February 2005, 23 had recurrent HCC. We studied the characteristics of 23 patients divided into two groups, according to the time of recurrence, namely, an early recurrence group (≤12 months) versus a late recurrence group (>12 months). Continuous variables were compared using Student t test and categorical variables using Fisher Exact Test. Statistical analysis was performed using SPSS 11.5 for Windows.
Results
Of 156 adult patients who received OLT for HCC from June 1996 to February 2005, 23 patients (14.7%) showed recurrences. They had received four cadaveric and 19 living donor liver transplantations due to HBV-related liver cirrhosis (n = 19), hepatitis C virus (HCV)-related liver cirrhosis (n = 2), HBV-related hepatitis (n = 1), HCV-related hepatitis (n = 1). The pathological stage according to the 6th AJCC/UICC was stage II in 12; stage IIIA in nine; stage IIIB in one; and stage IIIC in one.
Discussion
Tumor features that predict recurrence and poor prognosis after OLT for HCC include tumor size, number of tumors, micro/macrovascular invasion, high serum alpha-feto protein,1 and Milan criteria, which is one of the well-known predictors. In current studies, it has been suggested that immunostainings of the tumor, including p53, Ki-67,2 p-27, cyclin E, cyclin A,3 and cyclin D14 predict more rapid recurrence and poorer prognosis. In addition to these tumor features, we must consider the role of
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Cited by (19)
Transplantation Pathology
2023, MacSween's Pathology of the Liver, Eighth EditionTransplantation Pathology
2018, MacSween's Pathology of the LiverTransplantation pathology
2012, MacSween's Pathology of the LiverTransplantation Pathology
2011, MacSween's Pathology of the Liver: Expert Consult: Online and PrintSurgical Resection of Pulmonary Malignant Tumors After Living Donor Liver Transplantation
2009, Annals of Thoracic SurgeryCitation Excerpt :There were no problems or complications during the perioperative course in any of the repeated pulmonary resections. According to recent reports concerning pulmonary recurrence of HCC after liver transplantation, the pulmonary recurrence rate is 3.8 to 7.4% [4–6]. In these reports, most recurrences after liver transplantation develop during the first year after liver transplantation.
Recurrence of Hepatocellular Carcinoma After Liver Transplantation
2007, Transplantation ProceedingsCitation Excerpt :Avoidance is not possible due to the lack of adjuvant therapies.5 With adequate patient selection the recurrence rate is about 10%,2,3 preserving excellent survival after OLT. SPR is affected by the time from OLT to recurrence and the site of recurrence.